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PRAME [MD145R]
Description PRAME (preferentially expressed antigen in melanoma) is overexpressed in malignant cells, including primary and metastatic melanomas, acute and chronic leukaemias, Hodgkin’s lymphoma, breast cancer and head and neck squamous cell carcinomas. In AML (acute myeloid leukemia), high levels of PRAME are associated with lower relapse rate and high chances of disease-free survival. PRAME also plays a role in the retinol pathway. It modulates the metabolism of all-trans retinol (vitamin A) and its active metabolites, referred to as retinoids. It is a repressor of retinoic acid receptor signaling. Studies suggest that PRAME expression may be valuable for margin assessment of a known PRAME-positive melanoma, but its expression in nevi, solar lentigines, and benign nonlesional skin can represent a challenge. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€429,00 Add to cart -
PRAME [MD145R]
Description PRAME (preferentially expressed antigen in melanoma) is overexpressed in malignant cells, including primary and metastatic melanomas, acute and chronic leukaemias, Hodgkin’s lymphoma, breast cancer and head and neck squamous cell carcinomas. In AML (acute myeloid leukemia), high levels of PRAME are associated with lower relapse rate and high chances of disease-free survival. PRAME also plays a role in the retinol pathway. It modulates the metabolism of all-trans retinol (vitamin A) and its active metabolites, referred to as retinoids. It is a repressor of retinoic acid receptor signaling. Studies suggest that PRAME expression may be valuable for margin assessment of a known PRAME-positive melanoma, but its expression in nevi, solar lentigines, and benign nonlesional skin can represent a challenge. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€247,00 Add to cart -
ProExC (TOP2A&MCM2) [TOP2A/1362&MCM2/3678]
Description Minichromosome maintenance and topoisomerase II alpha proteins play an important role in the regulation of eukaryotic DNA replication, and are overexpressed in a number of dysplastic and malignant tissues. ProExC antibody is a novel biomarker cocktail containing antibodies against topoisomerase II alpha and minichromosome maintenance 2 proteins. When up regulated, ProExC serves as a marker of aberrant S-phase induction in proliferating cells. ProExC expression can be applied an independent risk factor for low grade squamous intraepithelial lesion (LSIL) progression. ProExC is a valuable marker for distinguishing dysplastic squamous and endocervical lesions of the cervix from squamous metaplasia, distinguishing adenocarcinoma in situ from reactive benign endocervix. ProExC may be used in conjunction with morphologic and human papillomavirus (HPV) evaluation for better classification of indeterminate cervical lesions in Papanicolaou smears. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€598,00 Add to cart -
ProExC (TOP2A&MCM2) [TOP2A/1362&MCM2/3678]
Description Minichromosome maintenance and topoisomerase II alpha proteins play an important role in the regulation of eukaryotic DNA replication, and are overexpressed in a number of dysplastic and malignant tissues. ProExC antibody is a novel biomarker cocktail containing antibodies against topoisomerase II alpha and minichromosome maintenance 2 proteins. When up regulated, ProExC serves as a marker of aberrant S-phase induction in proliferating cells. ProExC expression can be applied an independent risk factor for low grade squamous intraepithelial lesion (LSIL) progression. ProExC is a valuable marker for distinguishing dysplastic squamous and endocervical lesions of the cervix from squamous metaplasia, distinguishing adenocarcinoma in situ from reactive benign endocervix. ProExC may be used in conjunction with morphologic and human papillomavirus (HPV) evaluation for better classification of indeterminate cervical lesions in Papanicolaou smears. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€338,00 Add to cart -
Prolactin [MD140R]
Description Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and anti-apoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Prolactin [MD140R]
Description Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and anti-apoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
Prolactin Receptor [B6.2]
Description Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and anti-apoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Prolactin Receptor [B6.2]
Description Prolactin is a peptide hormone secreted by the anterior pituitary that is necessary for the proliferation and differentiation of the mammary glands. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth, differentiating and anti-apoptotic factor. Prolactin is secreted by lactotrophs in the anterior pituitary. Prolactin producing cells make up approximately 20 percent of the pituitary. Elevated counts of these cells have been observed in pregnant women, newborns and in multiparous women. An antibody to prolactin is useful for the identification of pituitary tumors (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Prostein [A5]
Description PSA, prostate specific antigen, is the classic indicator for transformed pro-state tissue; however, in addition to being upregulated in prostate cancer, PSA is also upregulated in non-malignant conditions, such as benign prostatic hyperplasia. Prostein, also designated Prostate cancer-associated protein 6, is a prostate-specific, 553 amino acid transmembrane protein that is upregulated by androgens. It is considered a marker for prostate cells since it is expressed in all prostatic glandular cells as well as in normal and cancerous prostate tissues. Since it is able to elicit a tumor-directed cytotoxic T cell response, Prostein may be used as a target for the development of PSA- and T cell-based therapeutic strategies for prostate cancer. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
pS2 Estrogen Inducible Protein [GE2]
Description This antibody specifically recognizes 6.5 kD human pS2 Estrogen-Regulated Protein. pS2 is specifically expressed and secreted by ER-mucosa cells of the normal stomach (antrum and body) of both female and male individuals. Primary breast tumors have been shown to express pS2 in ER+ primary breast tumors. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Cynomolgus Monkey
1 ml more info 14 days
€361,40 Add to cart
