Minichromosome maintenance and topoisomerase II alpha proteins play an important role in the regulation of eukaryotic DNA replication, and are overexpressed in a number of dysplastic and malignant tissues. ProExC antibody is a novel biomarker cocktail containing antibodies against topoisomerase II alpha and minichromosome maintenance 2 proteins. When up regulated, ProExC serves as a marker of aberrant S-phase induction in proliferating cells. ProExC expression can be applied an independent risk factor for low grade squamous intraepithelial lesion (LSIL) progression. ProExC is a valuable marker for distinguishing dysplastic squamous and endocervical lesions of the cervix from squamous metaplasia, distinguishing adenocarcinoma in situ from reactive benign endocervix. ProExC may be used in conjunction with morphologic and human papillomavirus (HPV) evaluation for better classification of indeterminate cervical lesions in Papanicolaou smears. (Shipping Cost: €200.00)

Cytokeratin 19 [RCK108]

Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. CK19 is synthesized mainly in embryonic and adult simple epithelia, but has also been found in non-keratinizing stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filaments, implying that regulation of its expression is different from other keratin-encoding genes. CK19 antibody is a useful tool for the identification of epithelial tumors. It is helpful in distinguishing hepatocellular carcinoma (CK19-) from cholangiocarcinoma (CK19+) or metastatic carcinoma in liver (CK19+).

Cytokeratin 19 [RCK108]