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PDGFRB [MD16R]
Description Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. Translocation of the PDGFR gene with the Tel gene is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse 
1 ml more info 
14 days 
€455,00 Add to cart -
PDGFRB [MD16R]
Description Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. Translocation of the PDGFR gene with the Tel gene is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€267,80 Add to cart -
PD-L1/PDCD1-L1/CD274 [MD21R]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€442,00 Add to cart -
PD-L1/PDCD1-L1/CD274 [MD21R]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
PD-L1/PDCD1-L1/CD274 [PDL1/2746]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€401,70 Add to cart -
PD-L1/PDCD1-L1/CD274 [PDL1/2746]
Description Programmed cell death 1 ligand 1 (PD-L1) also known as CD274 or B7-H1, a member of the B7 family of cell surface ligands, involved in regulation of T cell activation and humoral immune responses. The PD-L1 binds its transmember receptor PD-1 and provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy,tissue allografts, autoimmune disease and malignant transformation. PD-L1 is expressed in activated T and B cells, placenta and some tumors including melanoma, diffused large B-cell lymphoma, lung, ovary, colon, breast, rectum and renal cell carcinomas. Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma. Additional research links PD-L1 expression to cancers associated with viral infections. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
Perforin [E-5]
Description Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanism in T cellmediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Perforin [E-5]
Description Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanism in T cellmediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Perforin [PRF1/2470]
Description Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanism in T cellmediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Perforin [PRF1/2470]
Description Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanism in T cellmediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis. Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
