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PDGFRB [MD16R]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: MD16R
Host: Rabbit
Isotype: IgG
Application: Immunohistochemistry (IHC), Western Blot (WB)
Application notes: 20-100
Conjugation Type: Unconjugated
Reactivity: Human, Mouse
General notes: Localization: cytoplasm, membrane.
Buffer: EDTA pH8.0
UNSPSC code: 12352203

Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. Translocation of the PDGFR gene with the Tel gene is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. (Shipping Cost: €200.00)

PDGFRB [MD16R]

Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. Translocation of the PDGFR gene with the Tel gene is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.