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PLA2R/Phospholipase A2 receptor 1 [12-6-5]
Description This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified. Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of l Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€254,80 Add to cart -
PLA2R/Phospholipase A2 receptor 1 [EPR20483]
Description This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified. Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of l Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
PLA2R/Phospholipase A2 receptor 1 [EPR20483]
Description This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified. Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of l Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Plakophilin-2 [8H6]
Description Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains, and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin-1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration. Plakophilin-2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin-3 plays a role in both desmosome-dependent adhesion and signaling pathways. Plakophilin-4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€546,00 Add to cart -
Plasma Cells [LIV3G11 (7B18)]
Description Plasma cells, which are large lymphocytes derived from an antigen-specific B-cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B-cells upon stimulation by CD4+ lymphocytes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this antibody is not suitable for staining frozen tissues. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Plasma Cells [LIV3G11 (7B18)]
Description Plasma cells, which are large lymphocytes derived from an antigen-specific B-cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B-cells upon stimulation by CD4+ lymphocytes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this antibody is not suitable for staining frozen tissues. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Pneumocystis carinii/P. jiroveci [3F6]
Description Pneumocystis is a genus of fungi which can be pathogenic in mammals. Pneumocystis carinii, also referred to as Pneumocystis jiroveci, is a microscopic fungus that exists in the lungs of many humans. This fungus is normally benign, but it can cause Pneumocystis carinii pneumonia (PCP) in immunocompromised individuals. During PCP, Pneumocystis carinii deteriorates the basement membrane of the lung, causing a rise in LDH levels and compromising gas exchange. Oxygen is less able to diffuse into the blood, leading to hypoxia, which, along with high arterial CO2 levels, stimulates ventilation, thereby causing dyspnea. The fungus can also invade other visceral organs, such as the liver, spleen and kidney. Symptoms of Pneumocystis carinii infection include shortness of breath, non-productive cough, low grade fever, weight loss and night sweats. This disease can be fatal if not treated aggressively. This antibody reacts with a 82 kDa polypeptide specific to P. carinii. It does not cross-react Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Pneumocystis jiroveci infected tissues
1 ml more info 14 days
€361,40 Add to cart -
Pneumocystis carinii/P. jiroveci [3F6]
Description Pneumocystis is a genus of fungi which can be pathogenic in mammals. Pneumocystis carinii, also referred to as Pneumocystis jiroveci, is a microscopic fungus that exists in the lungs of many humans. This fungus is normally benign, but it can cause Pneumocystis carinii pneumonia (PCP) in immunocompromised individuals. During PCP, Pneumocystis carinii deteriorates the basement membrane of the lung, causing a rise in LDH levels and compromising gas exchange. Oxygen is less able to diffuse into the blood, leading to hypoxia, which, along with high arterial CO2 levels, stimulates ventilation, thereby causing dyspnea. The fungus can also invade other visceral organs, such as the liver, spleen and kidney. Symptoms of Pneumocystis carinii infection include shortness of breath, non-productive cough, low grade fever, weight loss and night sweats. This disease can be fatal if not treated aggressively. This antibody reacts with a 82 kDa polypeptide specific to P. carinii. It does not cross-react Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Pneumocystis jiroveci infected tissues
7 ml more info 14 days
€187,20 Add to cart -
Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker) [3D3]
Description Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Rabbit, Rat
1 ml more info 14 days
€361,40 Add to cart -
Podocalyxin (PODXL) (Hematopoietic Stem Cell Marker) [3D3]
Description Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Rabbit, Rat
7 ml more info 14 days
€187,20 Add to cart
