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PSMA [MD105R]
Description Prostate-specific membrane antigen (PSMA), also known as folate hydrolase 1(FOLH1), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. PSMA has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase Anti-PSMA labels normal prostate epithelial cells and prostate tumor cells. Although the expression of PSMA in neovasculature of a variety of solid tumors has been reported, PSMA expression is highly restricted to the prostate. It is a useful marker for prostate tumors. In prostate cancer, overexpression of PSMA is correlated with high tumor grade, non-diploid tumors, and advanced tumor stage. It can be used as an effective predictor for tumor progression in prostate cancer (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€234,00 Add to cart -
PTEN [6H2.1]
Description The PTEN protein is a lip phosphatase with tumor-suppressing abilities. Reduced of PTEN has been reported in a variety of malignancies, including breast, prostate, and endometrial cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage cancer. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€455,00 Add to cart -
PTEN [6H2.1]
Description The PTEN protein is a lip phosphatase with tumor-suppressing abilities. Reduced of PTEN has been reported in a variety of malignancies, including breast, prostate, and endometrial cancer. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage cancer. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€195,00 Add to cart -
RANKL/CD254 Polyclonal
Description RANKL or CD254 is expressed highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€374,40 Add to cart -
RANKL/CD254 Polyclonal
Description RANKL or CD254 is expressed highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
RAS (G12D Mutant Specific) Polyclonal
Description The guanine-nucleotide binding protein (K-Ras, H-Ras, and N-Ras) is 21 kDa membrane-associated GTPase which cycles between active (GTP-bound) and inactive (GDP-bound) forms, regulates cell proliferation, differentiation, and survival. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, studies show that in 30% of human cancers, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation is Gly12 to Asp12 (G12D) – Ras missense mutations at the codon 12, which results in decreased GTPase activity and constitutive signaling, possibly by increasing the overall rigidity of the protein. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€546,00 Add to cart -
Renal Cell Carcinoma (RCC)/Proximal Nephrogenic Antigen [66.4.C2]
Description Anti-renal cell carcinoma (RCC) recognizes a 200 kD glycoprotein localized in the brush border of the proximal renal tubule. This antibody immunoreacts with approximately 90% of primary renal cell carcinomas and approximately 85% of metastatic renal cell carcinomas. Therefore, anti-RCC is a reliable tool for differentiating primary or metastatic renal cell carcinoma from non-renal tumors. It may be utilized as a marker for the differential diagnosis of eosinophilic renal tumors-granular variant of renal cell carcinoma, chromophobe renal cell carcinoma, and oncocytoma. Other tumors that may react with this antibody are parathyroid adenoma and an occasional breast carcinoma. Nephroblastoma, oncocytoma, mesoblastic nephroma, transitional cell carcinoma, and angiomyolipoma are not labeled with this antibody. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Horse
1 ml more info 14 days
€361,40 Add to cart -
Renal Cell Carcinoma (RCC)/Proximal Nephrogenic Antigen [66.4.C2]
Description Anti-renal cell carcinoma (RCC) recognizes a 200 kD glycoprotein localized in the brush border of the proximal renal tubule. This antibody immunoreacts with approximately 90% of primary renal cell carcinomas and approximately 85% of metastatic renal cell carcinomas. Therefore, anti-RCC is a reliable tool for differentiating primary or metastatic renal cell carcinoma from non-renal tumors. It may be utilized as a marker for the differential diagnosis of eosinophilic renal tumors-granular variant of renal cell carcinoma, chromophobe renal cell carcinoma, and oncocytoma. Other tumors that may react with this antibody are parathyroid adenoma and an occasional breast carcinoma. Nephroblastoma, oncocytoma, mesoblastic nephroma, transitional cell carcinoma, and angiomyolipoma are not labeled with this antibody. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Western Blot (WB) Reactivity Human, Horse
7 ml more info 14 days
€187,20 Add to cart -
Respiratory Syncytial Virus (RSV) F Glycoprotein [5A6]
Description Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein is a Class I viral fusion protein. The Glycoprotein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the heptad repeat regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes, directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (protein F) interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between host cell and virion Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Retinol Binding Protein/RBP1 [G4E4]
Description This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (Shipping Cost: €200.00) Host Mouse Application Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Chimpanzee, Monkey, Goat, Rabbit, Rat, Mouse
1 ml more info 14 days
€361,40 Add to cart
