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Topoisomerase (DNA) I Mitochondrial (TOP1MT) [TOP1MT/488]
Description DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€361,40 Add to cart -
Topoisomerase II alpha [Ki-S1]
Description Topoisomerase IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC), Immunohistochemistry (IHC) IP, Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Topoisomerase II alpha [Ki-S1]
Description Topoisomerase IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC), Immunohistochemistry (IHC) IP, Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Topoisomerase II alpha [TOP2A/1362]
Description Topoisomerase IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Topoisomerase II alpha [TOP2A/1362]
Description Topoisomerase IIα plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
TOX3/TNRC9 [TOX3/1123]
Description It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Toxoplasma Gondii Polyclonal
Description Toxoplasma is a crescent shaped sporozoan that lives as an intracellular parasite in various tissues of many vertebrates and completes its life cycle in a single host. Its life cycle includes two phases called the intestinal (or enteroepithelial) and extraintestinal phases. The intestinal phase produces oocysts and occurs only in cats, wild as well as domesticated. The extraintestinal phase occurs in all infected animals including cats, and produces tachyzoites (actively proliferating trophozoites) and eventually, bradyzoites (slowly growing trophozoites) or zoitocysts. Infection due to Toxoplasma gondii occurs in pregnant women where a variable degree of immunosuppression may exist or in patients receiving immunosuppressive drug therapy. Toxoplasma infects tissue of the GI tract where an active infection is accompanied by fever and enlargement of the spleen. Symptoms of toxoplasmosis are generally mild but severe infection of lymph nodes may occur. Congenital toxoplasmosis, in which t Host Rabbit Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Whole organisms 
1 ml more info 14 days
€374,40 Add to cart -
TPIT1/TBX19 [CL6251]
Description T-box transcription factor (TBX19 or TPIT) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX19 is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€676,00 Add to cart -
TPO/Thyroid Peroxidase [MD118R]
Description Thyroid Peroxidase (TPO) is a membrane-bound protein, catalyzing iodide oxidation, iodination of tyrosine residues and generation of triiodothyronine and thyroxine. It is first synthesized within the endoplasmic reticulum (ER), where it can be readily detected. After folding to the native state within the ER, intracellular transport of TPO to the cell surface occurs via the Golgi complex, a compartment typically associated with N-glycan processing of many cell surface glycoproteins. TPO labels normal thyroid epithelial cells and thyroid tumor cells. The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
TPO/Thyroid Peroxidase [MD118R]
Description Thyroid Peroxidase (TPO) is a membrane-bound protein, catalyzing iodide oxidation, iodination of tyrosine residues and generation of triiodothyronine and thyroxine. It is first synthesized within the endoplasmic reticulum (ER), where it can be readily detected. After folding to the native state within the ER, intracellular transport of TPO to the cell surface occurs via the Golgi complex, a compartment typically associated with N-glycan processing of many cell surface glycoproteins. TPO labels normal thyroid epithelial cells and thyroid tumor cells. The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart
