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TPIT1/TBX19 [CL6251]
Product group: | Primary |
Monoclonal/ Polyclonal: | Monoclonal |
Clone: | CL6251 |
Host: | Mouse |
Isotype: | IgG1 |
Application: | Immunohistochemistry (IHC) |
Application notes: | 50-200 |
Conjugation Type: | Unconjugated |
Reactivity: | Human |
General notes: | Localization: nucleus. |
Buffer: | citrate pH6.0 or EDTA pH8.0 |
UNSPSC code: | 12352203 |
T-box transcription factor (TBX19 or TPIT) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX19 is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. (Shipping Cost: €200.00)
TPIT1/TBX19 [CL6251]
T-box transcription factor (TBX19 or TPIT) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX19 is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage.
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