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Transcription Factor PU.1/PU.1/Spi1 [EP18]
Description PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development. PU.1 stains B lymphocytes in germinal center and mantle B cells, but not plasma cells. It labels many types of B-cell lymphomas including mantle cell lymphoma, but is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lymphoproliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€494,00 Add to cart -
Transcription Factor PU.1/PU.1/Spi1 [EP18]
Description PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development. PU.1 stains B lymphocytes in germinal center and mantle B cells, but not plasma cells. It labels many types of B-cell lymphomas including mantle cell lymphoma, but is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lymphoproliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Transforming Growth Factor (TGF) alpha [1E8-G6]
Description Transforming Growth Factor, alpha (TGF-a ) is a 50 amino acid peptide that is involved in the regulation of normal and malignant cell growth. The mature peptide is released following proteolytic cleavage from a 160 amino acid transmembrane precursor molecule. It is one of the various ligands for EGFR and seem to be involved in the growth regulation of intestinal mucosa and might be related to the development and progression of gastrointestinal tumors. Macrophages secrete TGF-a to trigger proliferation of cancer cells. TGF-a is synthesized by several cells, like epidermal keratinocytes, fibroblasts, and cells of hematopoetic origin like eosinophils and stimulated macrophages. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Rabbit, Zebrafish
1 ml more info 14 days
€361,40 Add to cart -
Transforming Growth Factor (TGF) alpha [1E8-G6]
Description Transforming Growth Factor, alpha (TGF-a ) is a 50 amino acid peptide that is involved in the regulation of normal and malignant cell growth. The mature peptide is released following proteolytic cleavage from a 160 amino acid transmembrane precursor molecule. It is one of the various ligands for EGFR and seem to be involved in the growth regulation of intestinal mucosa and might be related to the development and progression of gastrointestinal tumors. Macrophages secrete TGF-a to trigger proliferation of cancer cells. TGF-a is synthesized by several cells, like epidermal keratinocytes, fibroblasts, and cells of hematopoetic origin like eosinophils and stimulated macrophages. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Rabbit, Zebrafish
7 ml more info 14 days
€187,20 Add to cart -
Transgelin (SM22-alpha) [SPM606]
Description This antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine,Pig (Porcine), Rabbit, Mouse
1 ml more info 14 days
€361,40 Add to cart -
Transglutaminase II [TGM2/419]
Description Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Rabbit, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Transglutaminase II [TGM2/419]
Description Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Rabbit, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Treponema Pallidum/Syphilis Polyclonal
Description Treponema pallidum is a species of spirochaete bacterium with subspecies that cause treponemal diseases such as syphilis, bejel, pinta and yaws. It is not seen on a Gram stained smear because the organism has a waxy coat around it that does not accept the Gram stain. Treponema pallidum is a Gram-negative spirochaete bacterium with periplasmic flagella. There are at least five subspecies of T. pallidum, including T. pallidum pallidum (the cause of syphilis), T. pallidum pertenue (the cause of yaws), T. pallidum carateum (the cause of pinta), T. pallidum trirocllium (the cause of syphilis and pinta) and T. pallidum endemicum (the cause of bejel). T. pallidum is motile and is generally transmitted through close sexual contact, entering the host via breaches in squamous or columnar epithelium. The microbe can also be transferred to a fetus by transplacental passage during the later stages of pregnancy, causing congenital syphilis. T. pallidum has one of the shortest bacterial genomes at on Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Treponema pallidum 
1 ml more info 14 days
€374,40 Add to cart -
TRIM29 [TRIM29/1041]
Description It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunofluorescence (IF) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
TRIM29 [TRIM29/1041]
Description It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunofluorescence (IF) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
