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Transforming Growth Factor (TGF) alpha [1E8-G6]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: 1E8-G6
Host: Mouse
Isotype: IgM
Application: Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application notes: Prediluted
Conjugation Type: Unconjugated
Lightchain type: Kappa
Reactivity: Human, Rabbit, Zebrafish
General notes: Localization: cytoplasm, secreted.
Buffer: citrate pH6.0
UNSPSC code: 12352203

Transforming Growth Factor, alpha (TGF-a ) is a 50 amino acid peptide that is involved in the regulation of normal and malignant cell growth. The mature peptide is released following proteolytic cleavage from a 160 amino acid transmembrane precursor molecule. It is one of the various ligands for EGFR and seem to be involved in the growth regulation of intestinal mucosa and might be related to the development and progression of gastrointestinal tumors. Macrophages secrete TGF-a to trigger proliferation of cancer cells. TGF-a is synthesized by several cells, like epidermal keratinocytes, fibroblasts, and cells of hematopoetic origin like eosinophils and stimulated macrophages. (Shipping Cost: €200.00)

Transforming Growth Factor (TGF) alpha [1E8-G6]

Transforming Growth Factor, alpha (TGF-a ) is a 50 amino acid peptide that is involved in the regulation of normal and malignant cell growth. The mature peptide is released following proteolytic cleavage from a 160 amino acid transmembrane precursor molecule. It is one of the various ligands for EGFR and seem to be involved in the growth regulation of intestinal mucosa and might be related to the development and progression of gastrointestinal tumors. Macrophages secrete TGF-a to trigger proliferation of cancer cells. TGF-a is synthesized by several cells, like epidermal keratinocytes, fibroblasts, and cells of hematopoetic origin like eosinophils and stimulated macrophages.