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TPO/Thyroid Peroxidase [MD118R]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: EP159
Host: Rabbit
Isotype: IgG
Application: Immunohistochemistry (IHC)
Application notes: 50-200
Conjugation Type: Unconjugated
Reactivity: Human
General notes: Localization: cytoplasm.
Buffer: citrate pH6.0 or EDTA pH8.0
UNSPSC code: 12352203

Thyroid Peroxidase (TPO) is a membrane-bound protein, catalyzing iodide oxidation, iodination of tyrosine residues and generation of triiodothyronine and thyroxine. It is first synthesized within the endoplasmic reticulum (ER), where it can be readily detected. After folding to the native state within the ER, intracellular transport of TPO to the cell surface occurs via the Golgi complex, a compartment typically associated with N-glycan processing of many cell surface glycoproteins. TPO labels normal thyroid epithelial cells and thyroid tumor cells. The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors. (Shipping Cost: €200.00)

TPO/Thyroid Peroxidase [EP159]

Thyroid Peroxidase (TPO) is a membrane-bound protein, catalyzing iodide oxidation, iodination of tyrosine residues and generation of triiodothyronine and thyroxine. It is first synthesized within the endoplasmic reticulum (ER), where it can be readily detected. After folding to the native state within the ER, intracellular transport of TPO to the cell surface occurs via the Golgi complex, a compartment typically associated with N-glycan processing of many cell surface glycoproteins. TPO labels normal thyroid epithelial cells and thyroid tumor cells. The expression level in thyroid carcinomas is lower than that of normal and benign thyroid tumors.