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ERCC6/CSB [D7]
Description DNA excision repair protein ERCC6, also known as Cockayne syndrome protein (CSB), is encoded by the ERCC6 gene in human. ERCC6 is the homolog of the yeast Rad26 protein. ERCC6 belongs in the SWI/SNF family of proteins as it contains helicase motifs and ATPase activity. It is a part of a complex that contains RNA pol I, TFIIH, and XPG, all of which are active in transcription and/or DNA repair. Hence, it is an essential factor involved in transcription-coupled nucleotide excision repair, which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is shown to be essential for transcription-coupled repair complex formation. It recruits the CSA complex (ERCC8 complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions. Mutat Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€455,00 Add to cart -
ERCC6/CSB [D7]
Description DNA excision repair protein ERCC6, also known as Cockayne syndrome protein (CSB), is encoded by the ERCC6 gene in human. ERCC6 is the homolog of the yeast Rad26 protein. ERCC6 belongs in the SWI/SNF family of proteins as it contains helicase motifs and ATPase activity. It is a part of a complex that contains RNA pol I, TFIIH, and XPG, all of which are active in transcription and/or DNA repair. Hence, it is an essential factor involved in transcription-coupled nucleotide excision repair, which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is shown to be essential for transcription-coupled repair complex formation. It recruits the CSA complex (ERCC8 complex), nucleotide excision repair proteins and EP300 to the sites of RNA polymerase II-blocking lesions. Mutat Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
ERG [MD188R]
Description ERG, the ETS related gene, belongs to the ETS family that plays important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. This family of transcription factors contains approximately 30 members that share a highly conserved DNA-binding domain (ETS domain) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain) and are thus distinguished in sub-families. The aberrant expression of several ETS proteins is involved in tumor development and progression. ERG belongs to the Erg/Fli-1 sub-family. Its involvement in human cancers has been widely studied. ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of proteins such as metalloprotease-1 (MMP-1) and MMP-3. EWS-ERG, or EWS-Fli-1 fusion, is a characteristic of Ewing’s sarcoma. TMPRSS2-ERG fusion, which occurs on account of transloca Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human Mouse, Rat
1 ml more info 14 days
€416,00 Add to cart -
ERG [MD188R]
Description ERG, the ETS related gene, belongs to the ETS family that plays important roles in cell development, differentiation, proliferation, apoptosis and tissue remodeling. This family of transcription factors contains approximately 30 members that share a highly conserved DNA-binding domain (ETS domain) and differs from each other in other domains (such as absence or presence of the Pointed/SAM domain) and are thus distinguished in sub-families. The aberrant expression of several ETS proteins is involved in tumor development and progression. ERG belongs to the Erg/Fli-1 sub-family. Its involvement in human cancers has been widely studied. ERG is linked to normal processes such as mesoderm formation and is found to form functional complexes with Jun/Fos, with the resulting ternary complexes regulating expression of proteins such as metalloprotease-1 (MMP-1) and MMP-3. EWS-ERG, or EWS-Fli-1 fusion, is a characteristic of Ewing’s sarcoma. TMPRSS2-ERG fusion, which occurs on account of transloca Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human Mouse, Rat
7 ml more info 14 days
€234,00 Add to cart -
EZH2/KMT6 [6G4F4]
Description EZH2 (enhancer of zeste homologue 2) or KMT6 or Enx1, is a polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. EZH2 and BMI-1 genes are coexpressed in Reed-Sternberg cells of Hodgkin’s disease. Coexpression of BMI-1 and EZH2 is also associated with cycling cells and degree of malignancy in B-cell non-Hogkin’s lymphoma. It is involved in the progression of prostate cancer, and has been identified as a marker of aggressive breast cancer. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€520,00 Add to cart -
Factor VIII Polyclonal
Description This antibody reacts with human von Willebrand factor, a large, multimeric protein synthesized by endothelial cells and stored in the Weibel-Palade granules. Studies have shown this antibody reacts specifically with the endothelial cells of normal, reactive, and neoplastic blood and lymphatic vessels, exhibiting a finely granular cytoplasmic staining. It also reacts with endocardium, platelets, and megakaryocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 14 days
€361,40 Add to cart -
Factor VIII Polyclonal
Description This antibody reacts with human von Willebrand factor, a large, multimeric protein synthesized by endothelial cells and stored in the Weibel-Palade granules. Studies have shown this antibody reacts specifically with the endothelial cells of normal, reactive, and neoplastic blood and lymphatic vessels, exhibiting a finely granular cytoplasmic staining. It also reacts with endocardium, platelets, and megakaryocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€163,80 Add to cart -
Factor XIII A [MD169R]
Description Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a Beta-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160kDa. Factor XIII is present in plasma as an alpha2Beta2 heterodimer (M.W. 320kDa); whereas in platelets, only the alpha2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Factor XIII A [MD169R]
Description Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a Beta-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160kDa. Factor XIII is present in plasma as an alpha2Beta2 heterodimer (M.W. 320kDa); whereas in platelets, only the alpha2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€214,50 Add to cart -
Factor XIII A [SPM180]
Description Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a Beta-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160kDa. Factor XIII is present in plasma as an alpha2Beta2 heterodimer (M.W. 320kDa); whereas in platelets, only the alpha2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart
