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B7-H4 [B7H4/2652R]
Description T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€234,00 Add to cart -
Beta-2-microglobulin [MD24R]
Description β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research; for example, research studies have shown that nearly one third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity (5); its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC),, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey
1 ml more info 14 days
€401,70 Add to cart -
Beta-2-microglobulin [MD24R]
Description β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research; for example, research studies have shown that nearly one third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity (5); its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC),, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€234,00 Add to cart -
BLC/BCA-1/CXCL13/B lymphocyte chemoattractant Polyclonal
Description Burkitt’s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B lymphocyte chemo-attractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B cell migration into splenic and Peyer’s patch follicles. BLC expression in Peyer’s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Dog 
1 ml more info 14 days
€494,00 Add to cart -
BLC/BCA-1/CXCL13/B lymphocyte chemoattractant Polyclonal
Description Burkitt’s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B lymphocyte chemo-attractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B cell migration into splenic and Peyer’s patch follicles. BLC expression in Peyer’s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Dog
7 ml more info 14 days
€254,80 Add to cart -
BMPR1B/ALK6 Polyclonal
Description On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.Involvement in disease; Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA). Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers).Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2). Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
BRAF V600E [MD58R]
Description Serine/threonine-protein kinase B-raf (BRAF) is a member of the Raf family. BRAF mutations are frequent in benign and malignant human tumors. BRAF V600E mutation accounts for the vast majority of BRAF alterations and the mutation induces a conformational change of the activation segment leading to a constitutive kinase activity of BRAF and consecutive phosphorylation of downstream targets. BRAF V600E mutation have been detected in melanoma, papillary thyroid carcinoma, pleomorphic xanthoastrocytomas, Langerhans cell histiocytosis, borderline ovarian cancer, ganglioglioma, colorectal carcinoma, and pilocytic astrocytoma. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€508,30 Add to cart -
BRCA1-associated Protein 1 (BAP1) [MD121R]
Description The BRCA-1 gene codes for a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The normal gene plays a role in repairing breaks in DNA. If a mutation occurs in this gene the repair function may become disabled thus leading to more DNA replication errors and neoplastic growth. Current findings suggest that BRCA-1 may play an as yet undefined protective role in cells, as it is strongly expressed in epithelial cells undergoing high levels of proliferation in association with differentiation. Additional findings have det ermined that complete loss of BRCA-1 nuclear expression in breast cancer and the correlation with poor prognostic markers imply that the altered BRCA-1 phenotype may provide an added prognostic parameter for breast cancer and could be applied for a potential rapid screening technique to identify BRCA-1 mutations (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
C1q Polyclonal
Description C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate. Expression of the mRNA, Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
C3d Polyclonal
Description Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. It was shown that anti-C3d labeled the epidermal basement membrane in 97% (31/32) cases of bullous pemphigoid (BP), with none of the normal controls demonstrating such findings. In the same study 27% (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart
