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BLC/BCA-1/CXCL13/B lymphocyte chemoattractant Polyclonal

Product group: Primary
Monoclonal/ Polyclonal: Polyclonal
Host: Rabbit
Isotype: IgG
Application: Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)
Application notes: 10-50
Conjugation Type: Unconjugated
Reactivity: Human, Dog
General notes: Localization: secreted.
Buffer: citrate pH6.0 or EDTA pH8.0
UNSPSC code: 12352203

Burkitt’s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B lymphocyte chemo-attractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B cell migration into splenic and Peyer’s patch follicles. BLC expression in Peyer’s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation. (Shipping Cost: €200.00)

BLC/BCA-1/CXCL13/B lymphocyte chemoattractant Polyclonal

Burkitt’s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B lymphocyte chemo-attractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B cell migration into splenic and Peyer’s patch follicles. BLC expression in Peyer’s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation.