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Desmin [D33]
Description Desmin is a characteristic intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle) and neoplasms associated with them. In general, desmin is a specific marker for myogenic differentiation among soft tissue tumors. It is seen in the majority of rhadbomyomas,leiomyomas, rhadbomyosarcoma, and leiomyosarcomas. Desmin is also seen in myofibroblasts. Myoepithelial cells typically lack desmin. The antibody labels smooth and striated muscle cells as well as mesothelial cells. It allows the subtyping of many undifferentiated and pleomorphic tumors through intermediate filament analysis. With selected panels of antibodies, it is a useful tool to separate the different pleomorphic spindle cell tumors and round cell tumors in soft tissues and skin. The antibody labels strongly reactive mesothelial cells, but not malignant mesothelioma and adenocarcinoma. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
Desmin [MD97R]
Description Desmin is a characteristic intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle) and neoplasms associated with them. In general, desmin is a specific marker for myogenic differentiation among soft tissue tumors. It is seen in the majority of rhadbomyomas,leiomyomas, rhadbomyosarcoma, and leiomyosarcomas. Desmin is also seen in myofibroblasts. Myoepithelial cells typically lack desmin. The antibody labels smooth and striated muscle cells as well as mesothelial cells. It allows the subtyping of many undifferentiated and pleomorphic tumors through intermediate filament analysis. With selected panels of antibodies, it is a useful tool to separate the different pleomorphic spindle cell tumors and round cell tumors in soft tissues and skin. The antibody labels strongly reactive mesothelial cells, but not malignant mesothelioma and adenocarcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€468,00 Add to cart -
Desmin [MD97R]
Description Desmin is a characteristic intermediate filament of all three types of muscle cells (skeletal, cardiac, and smooth muscle) and neoplasms associated with them. In general, desmin is a specific marker for myogenic differentiation among soft tissue tumors. It is seen in the majority of rhadbomyomas,leiomyomas, rhadbomyosarcoma, and leiomyosarcomas. Desmin is also seen in myofibroblasts. Myoepithelial cells typically lack desmin. The antibody labels smooth and striated muscle cells as well as mesothelial cells. It allows the subtyping of many undifferentiated and pleomorphic tumors through intermediate filament analysis. With selected panels of antibodies, it is a useful tool to separate the different pleomorphic spindle cell tumors and round cell tumors in soft tissues and skin. The antibody labels strongly reactive mesothelial cells, but not malignant mesothelioma and adenocarcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
Desmocollin-1/DSC1 [A4]
Description Desmocollin-1, also known as Cadherin family member 1 (CDHF1), is encoded by the DSC1 gene in human. Desmocollin-1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Desmocollins, along with the desmogleins, are found primarily in epithelial cells where they constitute the desmosomes, a type of cell junction required for cell adhesion. Desmocollins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmocollin interaction with intermediate filaments. The DSC1 gene comprises 17 exons spanning approximately 33 kb on 18q12.1, and the DSC3 gene comprises 17 exons spanning approximately 49 kb on 18q12.1. Alternative splicing gives rise to two DSC1 and DSC3 isoforms, designated 1A and 1B, and 3A and 3B, r Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Desmocollin-1/DSC1 [A4]
Description Desmocollin-1, also known as Cadherin family member 1 (CDHF1), is encoded by the DSC1 gene in human. Desmocollin-1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Desmocollins, along with the desmogleins, are found primarily in epithelial cells where they constitute the desmosomes, a type of cell junction required for cell adhesion. Desmocollins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmocollin interaction with intermediate filaments. The DSC1 gene comprises 17 exons spanning approximately 33 kb on 18q12.1, and the DSC3 gene comprises 17 exons spanning approximately 49 kb on 18q12.1. Alternative splicing gives rise to two DSC1 and DSC3 isoforms, designated 1A and 1B, and 3A and 3B, r Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Desmoglein-3 [5G11]
Description Desmoglein-3 (DSG3) is a calcium binding membrane protein that is localized desmosome cellular junctions and interacts with plaque proteins and intermediate filaments at cell-cell adhesion points. Desmosomes are cell-cell junctions between epithelial, myocardial and other cells types. In human keratinocytes, Desmoglein-3 (DSG3) is raft associated and disruption of rafts prevents desmosome assembly. DSG3 is one of four sister proteins in the desmoglein family. DSG3 is also the autoantigen for pemphigus vulgaris (PV) a lethal skin disease that is a result of autoantibodies against DSG3. DSG3 is over-expressed in lung squamous cell carcinomas (SQCC) but had very limited expression in both adenocarcinomas and non-neoplastic lungs. Using immunohistochemistry, the sensitivity and specificity of DSG3 for lung cancers were 98% and 99%, respectively, which is similar to that of p40. Therefore, DSG3 can be a useful ancillary marker to separate SQCC from other subtypes of lung cancer. (Shipping C Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Desmoglein-3 [5G11]
Description Desmoglein-3 (DSG3) is a calcium binding membrane protein that is localized desmosome cellular junctions and interacts with plaque proteins and intermediate filaments at cell-cell adhesion points. Desmosomes are cell-cell junctions between epithelial, myocardial and other cells types. In human keratinocytes, Desmoglein-3 (DSG3) is raft associated and disruption of rafts prevents desmosome assembly. DSG3 is one of four sister proteins in the desmoglein family. DSG3 is also the autoantigen for pemphigus vulgaris (PV) a lethal skin disease that is a result of autoantibodies against DSG3. DSG3 is over-expressed in lung squamous cell carcinomas (SQCC) but had very limited expression in both adenocarcinomas and non-neoplastic lungs. Using immunohistochemistry, the sensitivity and specificity of DSG3 for lung cancers were 98% and 99%, respectively, which is similar to that of p40. Therefore, DSG3 can be a useful ancillary marker to separate SQCC from other subtypes of lung cancer. (Shipping C Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
DOG-1 [DOG1.1]
Description DOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody. DOG1 identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
DOG-1 [DOG1.1]
Description DOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody. DOG1 identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Dopamine Polyclonal
Description Dopamine is a catecholamine neurotransmitter expressed mainly in the brain that activates dopamine receptors. Dopamine is also a neurohormone released by the hypothalamus. Its chemical name is 4-(2-aminoethyl)benzene-1,2-diol, and its main function is to inhibit the release of prolactin from the anterior lobe of the pituitary. Dopamine can be used as a sympathomimetic drug because it produces effects such as increased heart rate and blood pressure. Changes in Dopamine concentration within the brain may explain symptoms observed in individuals with Schizophrenia, and a reduction in its concentration is associated with Parkinson's disease. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 14 days
€494,00 Add to cart
