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TFE3 [EP285]
Description Xp11 translocation renal cell carcinoma (RCC) is a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus. Xp11 translocation RCC represents the most common type of RCC in children, but is less frequent on a percentage basis in adults. Morphologically, the neoplasm frequently shows papillary architecture and clear cytoplasm, and frequently has associated psammoma bodies. Immunohistochemically, the neoplasm under-expresses epithelial markers such as cytokeratin and epithelial membrane antigen compared with typical RCC. The most sensitive and specific immunohistochemical marker for the Xp11 translocation RCC is nuclear labeling of TFE3 protein, which reflects over-expression of the resulting fusion proteins relative to TFE3. Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma which affects predominantly young patients, Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€494,00 Add to cart -
TFF1/pS2 [MD119R]
Description Trefoil factor 1 (TFF1), a member of the trefoil factor family, also known as protein pS2 or breast cancer estrogen-inducible protein, is a stabilizer of the mucus gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability. TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract. The TFF1 antibody labels gastric mucosal cells, goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, epithelial cells lining the exocrine pancreatic ducts and breast epithelial cells. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€442,00 Add to cart -
TFF1/pS2 [MD119R]
Description Trefoil factor 1 (TFF1), a member of the trefoil factor family, also known as protein pS2 or breast cancer estrogen-inducible protein, is a stabilizer of the mucus gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability. TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract. The TFF1 antibody labels gastric mucosal cells, goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, epithelial cells lining the exocrine pancreatic ducts and breast epithelial cells. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
TFF3 [EPR3974]
Description refoil factors (TFFs) constitute a family of mucin-associated peptides containing one or more structurally characteristic trefoil domains. Trefoil factor 3 (TFF3) is a member of the trefoil family. They are mainly synthesized and secreted by mucin secreting epithelial cells lining the gastrointestinal tract and have a close association with mucins. TFF3 is expressed in goblet cells of the intestines and colon, eptihelial cells of the breast, prostate, thyroid, salivary gland and urinary tract. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
TFF3 [EPR3974]
Description refoil factors (TFFs) constitute a family of mucin-associated peptides containing one or more structurally characteristic trefoil domains. Trefoil factor 3 (TFF3) is a member of the trefoil family. They are mainly synthesized and secreted by mucin secreting epithelial cells lining the gastrointestinal tract and have a close association with mucins. TFF3 is expressed in goblet cells of the intestines and colon, eptihelial cells of the breast, prostate, thyroid, salivary gland and urinary tract. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Thomsen-Friedenreich Antigen / CD176 [SPM320]
Description Recognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. This MAb is capable to agglutinate desialylated red blood cells.During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysi Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Thrombomodulin (CD141) [D3]
Description Thrombomodulin (TM), also known as CD141, is an endothelial-specific type I membrane receptor that binds thrombin, resulting in the activation of protein C. This causes the degradation of clotting factors Va and VIIIa and reduces the amount of thrombin generated. Defect in Thrombomodulin is a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin was initially identified in endothelial cells. Its expression was also found in extra-vascular sites, such as in syncytiotrophoblasts in the placenta, epithelial tissues in the gingiva, in skin and in the synovial lining cells. In tumors, Thrombomodulin is expressed in vascular tumors and squamous cell carcinoma in a variety of tissues, including oral mucosa, esophagus and skin. Thrombomodulin is a marker for angiosarcoma. Additionally, anti-Thrombomodulin is useful in differentiating mesothelioma (positive) from lung adenocarcinoma (negative). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Thrombomodulin (CD141) [D3]
Description Thrombomodulin (TM), also known as CD141, is an endothelial-specific type I membrane receptor that binds thrombin, resulting in the activation of protein C. This causes the degradation of clotting factors Va and VIIIa and reduces the amount of thrombin generated. Defect in Thrombomodulin is a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin was initially identified in endothelial cells. Its expression was also found in extra-vascular sites, such as in syncytiotrophoblasts in the placenta, epithelial tissues in the gingiva, in skin and in the synovial lining cells. In tumors, Thrombomodulin is expressed in vascular tumors and squamous cell carcinoma in a variety of tissues, including oral mucosa, esophagus and skin. Thrombomodulin is a marker for angiosarcoma. Additionally, anti-Thrombomodulin is useful in differentiating mesothelioma (positive) from lung adenocarcinoma (negative). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Thrombospondin 1 [A6.1]
Description The Thrombospondin proteins (TSP 1-4) compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Thrombospondins play a role in development, aggregation of platelets, adhesion and migration of cells and progression of cells through the growth cycle. Thrombospondin 1 is released from platelets in response to Thrombin stimulation and is a transient component of the extracellular matrix of developing and repairing tissues. Thrombospondin 2 shares a high degree of homology with TSP 1, and is thought to have overlapping but unique functions. Thrombospondin 3 is a developmentally regulated heparin binding protein. Thrombospondin 4 is neuronally expressed and stimulates neurite outgrowth. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Sheep, Horse, Bovine, Dog (Canine),Pig (Porcine)
1 ml more info 14 days
€361,40 Add to cart -
Thrombospondin 1 [A6.1]
Description The Thrombospondin proteins (TSP 1-4) compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Thrombospondins play a role in development, aggregation of platelets, adhesion and migration of cells and progression of cells through the growth cycle. Thrombospondin 1 is released from platelets in response to Thrombin stimulation and is a transient component of the extracellular matrix of developing and repairing tissues. Thrombospondin 2 shares a high degree of homology with TSP 1, and is thought to have overlapping but unique functions. Thrombospondin 3 is a developmentally regulated heparin binding protein. Thrombospondin 4 is neuronally expressed and stimulates neurite outgrowth. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, Sheep, Horse, Bovine, Dog (Canine),Pig (Porcine)
7 ml more info 14 days
€187,20 Add to cart
