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Thrombomodulin (CD141) [D3]

Product group: Primary
Monoclonal/ Polyclonal: Monoclonal
Clone: D3
Host: Mouse
Isotype: IgG2a
Application: Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application notes: 50-250
Conjugation Type: Unconjugated
Reactivity: Human
General notes: Localization: cytoplasm, membrane.
Buffer: citrate pH6.0 or EDTA pH8.0
UNSPSC code: 12352203

Thrombomodulin (TM), also known as CD141, is an endothelial-specific type I membrane receptor that binds thrombin, resulting in the activation of protein C. This causes the degradation of clotting factors Va and VIIIa and reduces the amount of thrombin generated. Defect in Thrombomodulin is a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin was initially identified in endothelial cells. Its expression was also found in extra-vascular sites, such as in syncytiotrophoblasts in the placenta, epithelial tissues in the gingiva, in skin and in the synovial lining cells. In tumors, Thrombomodulin is expressed in vascular tumors and squamous cell carcinoma in a variety of tissues, including oral mucosa, esophagus and skin. Thrombomodulin is a marker for angiosarcoma. Additionally, anti-Thrombomodulin is useful in differentiating mesothelioma (positive) from lung adenocarcinoma (negative). (Shipping Cost: €200.00)

Thrombomodulin (CD141) [D3]

Thrombomodulin (TM), also known as CD141, is an endothelial-specific type I membrane receptor that binds thrombin, resulting in the activation of protein C. This causes the degradation of clotting factors Va and VIIIa and reduces the amount of thrombin generated. Defect in Thrombomodulin is a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin was initially identified in endothelial cells. Its expression was also found in extra-vascular sites, such as in syncytiotrophoblasts in the placenta, epithelial tissues in the gingiva, in skin and in the synovial lining cells. In tumors, Thrombomodulin is expressed in vascular tumors and squamous cell carcinoma in a variety of tissues, including oral mucosa, esophagus and skin. Thrombomodulin is a marker for angiosarcoma. Additionally, anti-Thrombomodulin is useful in differentiating mesothelioma (positive) from lung adenocarcinoma (negative).