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p53 [DO-7]
Description p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 is overexpressed in over 50% of human cancers. Positive staining of p53 detected by immunohistochemistry has been observed in colon cancer, breast cancer, lung cancer, prostate cancer and ovary cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Bovine, Monkey 
1 ml more info 
14 days 
€361,40 Add to cart -
p53 [DO-7]
Description p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 is overexpressed in over 50% of human cancers. Positive staining of p53 detected by immunohistochemistry has been observed in colon cancer, breast cancer, lung cancer, prostate cancer and ovary cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Bovine, Monkey
7 ml more info 14 days
€187,20 Add to cart -
p57/Kip2 [KP10]
Description p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
p57/Kip2 [KP10]
Description p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
p62/SQSTM1 [MD61]
Description Adapter protein Sequestosome 1 (SQSTM1, p62) is an ubiquitin binding protein involved in cell signaling, oxidative stress, and autophagy. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Defects in SQSTM1 are a cause of Paget disease of bone (PDB). PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
p63 [4A4]
Description The p63 protein is a member of the p53 family, which also includes p73. At least 6 different transcripts of p63 derives from alternative splicing events and encodes proteins with two different N termini (TA and DN) and three different C termini (a, b and g). p63 protein is detected in proliferating cells of epithelium, cervix, urothelium and prostate. It is also expressed in most poorly differentiated squamous cell carcinomas. The delta Np63 isoform is also abundantly expressed in nasopharyngeal carcinomas. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. These basal cells act as the progenitors of the suprabasal cells, which undergo differentiation and cell death in regenerative epithelia. p63 is also an essential gene that is critical for regenerative proliferation of cells involved in limb, craniofacial and epidermal morphogenesis. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€388,70 Add to cart -
p63 [4A4]
Description The p63 protein is a member of the p53 family, which also includes p73. At least 6 different transcripts of p63 derives from alternative splicing events and encodes proteins with two different N termini (TA and DN) and three different C termini (a, b and g). p63 protein is detected in proliferating cells of epithelium, cervix, urothelium and prostate. It is also expressed in most poorly differentiated squamous cell carcinomas. The delta Np63 isoform is also abundantly expressed in nasopharyngeal carcinomas. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. These basal cells act as the progenitors of the suprabasal cells, which undergo differentiation and cell death in regenerative epithelia. p63 is also an essential gene that is critical for regenerative proliferation of cells involved in limb, craniofacial and epidermal morphogenesis. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
p63 [TP63/11]
Description The p63 protein is a member of the p53 family, which also includes p73. At least 6 different transcripts of p63 derives from alternative splicing events and encodes proteins with two different N termini (TA and DN) and three different C termini (a, b and g). p63 protein is detected in proliferating cells of epithelium, cervix, urothelium and prostate. It is also expressed in most poorly differentiated squamous cell carcinomas. The delta Np63 isoform is also abundantly expressed in nasopharyngeal carcinomas. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. These basal cells act as the progenitors of the suprabasal cells, which undergo differentiation and cell death in regenerative epithelia. p63 is also an essential gene that is critical for regenerative proliferation of cells involved in limb, craniofacial and epidermal morphogenesis. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
p63 [TP63/11]
Description The p63 protein is a member of the p53 family, which also includes p73. At least 6 different transcripts of p63 derives from alternative splicing events and encodes proteins with two different N termini (TA and DN) and three different C termini (a, b and g). p63 protein is detected in proliferating cells of epithelium, cervix, urothelium and prostate. It is also expressed in most poorly differentiated squamous cell carcinomas. The delta Np63 isoform is also abundantly expressed in nasopharyngeal carcinomas. The predominant localization of p63 protein is in the basal layer of stratified squamous and transitional epithelia. These basal cells act as the progenitors of the suprabasal cells, which undergo differentiation and cell death in regenerative epithelia. p63 is also an essential gene that is critical for regenerative proliferation of cells involved in limb, craniofacial and epidermal morphogenesis. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Parafibromin/HRPT2/CDC73 [2H1]
Description Parathyroid tumors are heterogeneous and diagnosis of the disease is often difficult. The Parafibromin protein may be important as a marker for diagnosing parathyroid carcinoma. Parafibromin is encoded by the endocrine tumor suppressor gene CDC73 (cell division cycle 73, Paf1/RNA polymerase II complex component), alternatively known as the HRPT2 (hyperparathyroidism-jaw tumor syndrome 2) gene. The human CDC73 gene, which maps to chromosome 1q25, is the human homolog of Saccharomyces cerevisiae Cdc73 and is responsible for the hyperparathyroidism with jaw tumor syndrome (HPT-JT). Parafibromin is part of the RNA polymerase II/Paf1 complex, which is crucial for histone modification. This Parafibromin complex binds to both the nonphosphorylated forms and the Ser 2 and Ser 5 phosphorylated forms of the RNA polymerase II large subunit. (Shipping Cost: €200.00) Host Mouse Application Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart
