You are here
Products
p57/Kip2 [KP10]
Product group: | Primary |
Monoclonal/ Polyclonal: | Monoclonal |
Clone: | KP10 |
Host: | Mouse |
Isotype: | IgG2b |
Application: | Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) |
Application notes: | 100-300 |
Conjugation Type: | Unconjugated |
Lightchain type: | Kappa |
Reactivity: | Human, Mouse |
General notes: | Localization: nucleus. |
Buffer: | citrate pH6.0 or EDTA pH8.0 |
UNSPSC code: | 12352203 |
p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive). (Shipping Cost: €200.00)
p57/Kip2 [KP10]
p57Kip2 is a potent, tight-binding inhibitor of several G1 cyclin/Cdk complexes, and its binding is cyclin dependent. Its over-expression leads to arrest of the cell in G1 phase. Human p57Kip2 appears to have conserved the amino- and carboxy-terminal domains but has replaced the internal regions with sequences containing proline-alanine repeats. Expression patterns suggest a complex role for p57Kip2 cell cycle control and development. Because complete hydatidiform moles lack a maternal genome, p57Kip2 immunostaining is correspondingly absent, whereas hydropic abortuses and partial moles show positive staining. p57Kip2 is a marker distinguishing complete hydatidiform moles (negative) from partial moles (positive).
Alternative names: