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Cadherin-E/CD324 [MD128R]
Description E-Cadherin is a transmembrane glycoprotein, plays an important role in epithelial cell adhesion. A decreased expression of E-Cadherin is associated with metastatic potential and poor prognosis in breast cancer and esophagus cancer. In combination with p120 Catenin or Cytokeratin, it is useful for the differentiation between ductal (E-Cadherin positive) and lobular (E-Cadherin negative) breast carcinomas. It may also help in diagnosis of mesothelioma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human -
Cadherin-K/CDH6 [MD129R]
Description Cadherin-6 is a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. It is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Cadherin-6 is highly expressed in kidney and the central nervous system. It has been found to be related to fetal kidney development and has been identified as a major cadherin in renal proximal tubules where conventional renal cell carcinoma originates. The expression of Cadherin-6 is associated with tumor progression in renal cell carcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human -
Cadherin-K/CDH6 [MD129R]
Description Cadherin-6 is a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. It is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Cadherin-6 is highly expressed in kidney and the central nervous system. It has been found to be related to fetal kidney development and has been identified as a major cadherin in renal proximal tubules where conventional renal cell carcinoma originates. The expression of Cadherin-6 is associated with tumor progression in renal cell carcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human -
Cadherin-ksp [MD127R]
Description Kidney-specific cadherin, also known as Cadherin-16, is a member of the calcium dependent family of adhesion molecules that play important roles during embryonic development, maintenance of tissue architecture and growth control during tumorigenesis. In the kidney, Ksp-cadherin expression is uniquely localized predominantly in the distal portion of the nephron. There are four major subtypes of renal neoplasms; clear cell and papillary renal cell carcinoma are thought to be of proximal tubular origin, while oncocytoma and chromophobe renal cell carcinoma (RCC) are derived from cells of the distal nephron. Studies have shown high sensitivity and specificity of Ksp-cadherin to chromophobe RCC (86-100%) and oncocytoma (76-95%). Conversely, low reactivity was observed with clear cell RCC (14-30%) and papillary RCC (0-13%), supporting the use of Ksp-cadherin as a marker for the distal portion of the nephron, and for its use as an adjunct for the detection of chromophobe RCC and oncocytoma. ( Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human -
Cadherin-ksp/CDH16 [CDH16/1071]
Description Kidney specific. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human -
Cadherin-ksp/CDH16 [CDH16/1071]
Description Kidney specific. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human -
Calcitonin Gene Related Peptide/CGRP [4901]
Description Calcitonin Gene Related Peptide or CGRP is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known. It is primarily produced in nervous tissue and its receptors are expressed throughout the body. CGRP is strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (PFA fixed), Immunohistochemistry on frozen sections (IHC-Fs), Immunoprecipitation (IP) Reactivity Human, Mouse, Rat, Dog Guinea Pig -
Caldesmon [EP19]
Description Caldesmon is a smooth muscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin. It is more specific to smooth muscle differentiation than desmin and muscle specific actin. Also, it is useful in differentiation of smooth muscle from myofibroblast tumors, uterus leiomyoma from endometrial stroma tumor. Caldesmon is a marker for identification of epitheloid mesothelioma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human -
Caldesmon [EP19]
Description Caldesmon is a smooth muscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin. It is more specific to smooth muscle differentiation than desmin and muscle specific actin. Also, it is useful in differentiation of smooth muscle from myofibroblast tumors, uterus leiomyoma from endometrial stroma tumor. Caldesmon is a marker for identification of epitheloid mesothelioma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human -
Caldesmon, HMW (h-Caldesmon) [h-CALD]
Description Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. This MAb recognizes only the 150kDa variant (h-Caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human