You are here
-
Villin [VIL1/1314]
Description Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium. This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs. This antibody also labels Merkel cells of the skin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
Wilms' Tumor (WT1) [6F-H2]
Description Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm’s tumor, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Wilms' Tumor (WT1) [6F-H2]
Description Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm’s tumor, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
FOXO1/FKHR (C9]
Description Forkhead box O (FOXO) or FKHR (forkhead in rhabdomyosarcoma is a member of the forkhead family of transcription factors which plays an important role in modulating metabolic functions. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€390,00 Add to cart -
FOXO1/FKHR (C9]
Description Forkhead box O (FOXO) or FKHR (forkhead in rhabdomyosarcoma is a member of the forkhead family of transcription factors which plays an important role in modulating metabolic functions. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
LPA [4H1]
Description The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Sheep, Bovine
1 ml more info 14 days
€572,00 Add to cart -
LPAR1/EDG-2 [B10]
Description The EDG (endothelial differentiation gene) family of GPC-receptors consists of eight family members (EDG1-8) that bind lysophospholipid (LPL) mediators either sphingosine-1-phosphate (SPP) or lysophosphatidic acid (LPA). EDG1, EDG3, EDG5 and EDG8 bind SPP with high affinity and EDG6 with low affinity. EDG2, EDG4 and EDG7 bind LPA preferentially. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG2 or LPAR1, expressed in brain especially in white matter tract regions, interacts with RALA, ADRBK1 etc. In the absence of LPA, it can be found predominantly at the cell surface; whereas in the presence of LPA, it co-localizes with RALA in the endocytic vesicles. It is well established that platelets, certain inflammatory cells, nerve cells, endothelial cells, cancerous cells etc. are triggered to release LPA in autocrine/paracrine fashion with Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Selenoprotein P/SEPP1 [B9]
Description Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of selenoproteins. Nutritional deficiency of selenium decreases selenoprotein concentrations and leads to pathologic conditions. Selenoprotein P (SEPP1) is a major selenoprotein that is not a member of those families. It is an extracellular glycoprotein that is present in several isoforms and is the only selenoprotein known to contain multiple selenocysteine residues. A growing body of evidence relates selenium to cancer prevention, immune system function, male fertility, cardiovascular disorder, control of the aging and neurodiseases process. Selenoproteins are thought to be responsible for the majority of these biomedical effects of selenium. It has been also implicated in the regulation of signaling pathways through catalysis of thiol/disulfide exchange. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
Selenoprotein P/SEPP1 [B9]
Description Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of selenoproteins. Nutritional deficiency of selenium decreases selenoprotein concentrations and leads to pathologic conditions. Selenoprotein P (SEPP1) is a major selenoprotein that is not a member of those families. It is an extracellular glycoprotein that is present in several isoforms and is the only selenoprotein known to contain multiple selenocysteine residues. A growing body of evidence relates selenium to cancer prevention, immune system function, male fertility, cardiovascular disorder, control of the aging and neurodiseases process. Selenoproteins are thought to be responsible for the majority of these biomedical effects of selenium. It has been also implicated in the regulation of signaling pathways through catalysis of thiol/disulfide exchange. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
TCR γ/δ (TCR gamma/delta) [H41]
Description T-cell receptor (TCR), a heterodimer composed of either α and β or γ and δ chains, recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Most human T cells (95%) express the α/β or either CD4 or CD8 molecule (single positive, SP), while 2-5% express the γ/δ. However, a small number of T cells lack both CD4 and CD8 (double negative, DN). T helper cells express CD4 proteins and T cytotoxic cells display CD8. Increased percentages of α/β DN T cells have been identified in some autoimmune and immunodeficiency disorders. γ/δ T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than α/β T cells. Subsets of γ/δ T cells have shown antitumor and immunoregulatory activity. (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart
