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IL-4 Polyclonal
Description Interleukin-4 (IL-4), also knowns as a B-cell stimulatory factor1 (BSF1), is an immunomodulatory cytokine, which can inhibit the growth of tumor cells. The human cDNA contains a single open reading frame encoding a protein of 153 amino acids, including a putative signal peptide. IL-4 may act as an autocrine growth factor in pancreatic cancer cells and also give rise to the possibility that cancer-derived IL-4 may suppress cancer-directed immunosurveillance in vivo in addition to its growth-promoting effects, thereby facilitating pancreatic tumor growth and metastasis. The mouse and human genes and their protein products show structural and functional similarities. The human IL-4 gene, which occurs as a single copy in the haploid genome, is mapped on chromosome 5. The standard product used in this kit is recombinant human IL-4, consisting of 130 amino acids with the molecular mass of 14 KDa. Participates in at least several B-cell activation processes as well as of other cell types. It Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€374,40 Add to cart -
IRAK2 Polyclonal
Description IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€494,00 Add to cart -
IRAK2 Polyclonal
Description IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
KRAS Polyclonal
Description This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
LI/Leukemia Inhibitory Factor Polyclonal
Description LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Musashi2 (Msi2) Polyclonal
Description Musashi 2 (Msi2) protein, a regulator of mRNA translation, was consistently elevated in metastasis-competent cell lines. Msi2 is reported to be a potential oncoprotein in cases of leukemia and several solid tumors. The Msi2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukemia and stem cell function. The Msi2 RNA-binding protein is a potent oncogene playing key roles in hematopoietic stem cell homeostasis and malignant hematopoiesis. Msi2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinomas, and that Msi2 loss-of-function abrogates colorectal cancer cell growth.Msi2 is highly expressed in human myeloid leukemia (AML) cell lines, and high expression of Msi2 mRNA is associated with decreased survival in AML, suggesting its use as a new prognostic marker. It has been demonstrated that Msi2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and may be a valu Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€401,70 Add to cart -
Myeloperoxidase (MPO) Polyclonal
Description Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophil granulocytes (NGs). Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products, which are proposed to contribute to tissue damage during inflammation. MPO is a marker for myeloid cells. It may also be weakly expressed in cells of monocytic origin. It is useful for differentiating acute myelogenous leukemia from acute lymphoblastic leukemia, In addition, MPO is thought to be involved in the pathology Alzheimer’s disease. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Myeloperoxidase (MPO) Polyclonal
Description Myeloperoxidase (MPO), a heme protein, is a major component of azurophilic granules of neutrophil granulocytes (NGs). Optimal oxygen-dependent microbicidal activity depends on MPO as the critical enzyme for the generation of hypochlorous acid and other toxic oxygen products, which are proposed to contribute to tissue damage during inflammation. MPO is a marker for myeloid cells. It may also be weakly expressed in cells of monocytic origin. It is useful for differentiating acute myelogenous leukemia from acute lymphoblastic leukemia, In addition, MPO is thought to be involved in the pathology Alzheimer’s disease. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
NIRF/UHRF2 Polyclonal
Description NIRF (Np95/ICBP90-like RING finger protein), also known as E3 ubiquitin-protein ligase UHRF2, Nuclear zinc finger protein Np97 or RING finger protein 107, is a nuclear protein involved in cell cycle regulation. NIRF contains a PHD finger, two RING fingers, a ubiquitin-like domain and a YDG/SRA domain. It shares high structural homology with UHRF1 (also called ICBP90 in humans and Np95 in mice), however, in contrast to UHRF1, NIRF acts as a negative regulator of cell proliferation. It associates with the Cdk2-cyclin complex in its dephosphorylated form and induces G1 arrest. NIRF plays an important role in the regulation of the G1/S transition by blocking cell entry into the S-phase. While associated with Cdk2, NIRF becomes phosphorylated. NIRF can also act as a ubiquitin ligase and it ubiquitinates PCNP. In addition, NIRF can recruit and bind HDAC1 via its SRA domain. The overexpression of NIRF results in an increase of G1 phase cells. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat, Bovine
1 ml more info 14 days
€455,00 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart
