Musashi 2 (Msi2) protein, a regulator of mRNA translation, was consistently elevated in metastasis-competent cell lines. Msi2 is reported to be a potential oncoprotein in cases of leukemia and several solid tumors. The Msi2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukemia and stem cell function. The Msi2 RNA-binding protein is a potent oncogene playing key roles in hematopoietic stem cell homeostasis and malignant hematopoiesis. Msi2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinomas, and that Msi2 loss-of-function abrogates colorectal cancer cell growth.Msi2 is highly expressed in human myeloid leukemia (AML) cell lines, and high expression of Msi2 mRNA is associated with decreased survival in AML, suggesting its use as a new prognostic marker. It has been demonstrated that Msi2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and may be a valu

CD137/4-1BB/TNFRSF9 Polyclonal

CD137 or 4-1BB is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I and TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.

CD137/4-1BB/TNFRSF9 Polyclonal