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Cereblon/CRBN Polyclonal
Description Cereblon or CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. Cereblon functions energy metabolism, learning and memory. Cereblon acts as a protease in mitochondria and regulates the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding Cereblon belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the Cereblon gene are associated with mild mental retardation. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€494,00 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€163,80 Add to cart -
Cyclin B3 (CCNB3) Polyconal
Description Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. Cyclin B3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Dog (Canine), Horse,Pig (Porcine), Sheep
7 ml more info 14 days
€174,20 Add to cart -
Cyclin B3 (CCNB3) Polyconal+B200
Description Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. Cyclin B3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin may associate with CDC2 and CDK2 kinases, and be required for proper spindle reorganization and restoration of the interphase nucleus. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Dog (Canine), Horse,Pig (Porcine), Sheep
1 ml more info 14 days
€494,00 Add to cart -
DAZL/SPGYLA/TPX2 Polyclonal
Description DAZL (Deleted in azoospermia-like 1; SPGY-like-autosomal) is an RNA-binding protein that interacts with mRNA transcripts by its N-terminal RNA recognition motifs. It is the product of the Y-linked DAZ gene, and is found exclusively in the testes. DAZL regulates gene expression during spermatogenesis and may shuttle between the nucleus and cytoplasm during various stages of this process. It interacts with other proteins of the DAZ family via its DAZ-like domain, including DAZ, BOLL, DAZAP1, DAZAP2, and PUM2. Disruption of DAZL expression may play a role in male infertility. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Mouse, Bovine
1 ml more info 14 days
€494,00 Add to cart -
EBER Associated Protein/RPL22 Polyclonal
Description Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3 Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Bovine, Monkey,Pig (Porcine)
1 ml more info 14 days
€598,00 Add to cart -
Endothelin A Receptor/ETAR/EDNRA Polyclonal
Description This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
FLI-1 Polyclonal
Description The FLI-1 gene and FLI-1 protein are best known for their critical role in the pathogenesis of ES/PNET. More than 85% of ES/PNET are characterized by the translocation t(11;22)(q24;q12) that results in the fusion of the ews gene on chromosome 22 to the FLI-1 gene on chromosome 11. FLI-1 is a member of the ETS (erythroblastosis virus-associated transforming sequences) family of DNA-binding transcription factors and is involved in cellular proliferation and tumorigen esis. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown in two recent studies to be valuable in the discrimination of ES/PNET from most of its potential mimics, with the notable exception of lymphoblastic lymphoma. The FLI-1 gene has also recently been shown to play an important role in the embryologic development of blood vessels. FLI-1 is a highly sensitive (92%) and specific (100%) marker of both benign an Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
FLI-1 Polyclonal
Description The FLI-1 gene and FLI-1 protein are best known for their critical role in the pathogenesis of ES/PNET. More than 85% of ES/PNET are characterized by the translocation t(11;22)(q24;q12) that results in the fusion of the ews gene on chromosome 22 to the FLI-1 gene on chromosome 11. FLI-1 is a member of the ETS (erythroblastosis virus-associated transforming sequences) family of DNA-binding transcription factors and is involved in cellular proliferation and tumorigen esis. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown in two recent studies to be valuable in the discrimination of ES/PNET from most of its potential mimics, with the notable exception of lymphoblastic lymphoma. The FLI-1 gene has also recently been shown to play an important role in the embryologic development of blood vessels. FLI-1 is a highly sensitive (92%) and specific (100%) marker of both benign an Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€267,80 Add to cart
