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FLI-1 Polyclonal

Product information References Bioinformatics Documents
Product group: Primary
Monoclonal/ Polyclonal: Polyclonal
Host: Rabbit
Isotype: IgG1
Application: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application notes: 25-100
Conjugation Type: Unconjugated
Reactivity: Human, Mouse, Rat
General notes: Localization: nucleus.
Buffer: citrate pH6.0
UNSPSC code: 12352203

The FLI-1 gene and FLI-1 protein are best known for their critical role in the pathogenesis of ES/PNET. More than 85% of ES/PNET are characterized by the translocation t(11;22)(q24;q12) that results in the fusion of the ews gene on chromosome 22 to the FLI-1 gene on chromosome 11. FLI-1 is a member of the ETS (erythroblastosis virus-associated transforming sequences) family of DNA-binding transcription factors and is involved in cellular proliferation and tumorigen esis. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown in two recent studies to be valuable in the discrimination of ES/PNET from most of its potential mimics, with the notable exception of lymphoblastic lymphoma. The FLI-1 gene has also recently been shown to play an important role in the embryologic development of blood vessels. FLI-1 is a highly sensitive (92%) and specific (100%) marker of both benign an

FLI-1 Polyclonal

The FLI-1 gene and FLI-1 protein are best known for their critical role in the pathogenesis of ES/PNET. More than 85% of ES/PNET are characterized by the translocation t(11;22)(q24;q12) that results in the fusion of the ews gene on chromosome 22 to the FLI-1 gene on chromosome 11. FLI-1 is a member of the ETS (erythroblastosis virus-associated transforming sequences) family of DNA-binding transcription factors and is involved in cellular proliferation and tumorigen esis. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown in two recent studies to be valuable in the discrimination of ES/PNET from most of its potential mimics, with the notable exception of lymphoblastic lymphoma. The FLI-1 gene has also recently been shown to play an important role in the embryologic development of blood vessels. FLI-1 is a highly sensitive (92%) and specific (100%) marker of both benign and malignant vascular tumors. FLI-1 expression in the nonvascular sarcomas, melanomas, or carcinomas studied was not observed.