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p27/Kip1 [DCS-72.F6]
Description p27Kip1 is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27Kip1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitination and degradation of p27Kip1, while phosphorylation by hKIS on S10 signals nuclear export to the cytoplasm. The expression level of p27Kip1 is high in normal cells. Downregulation of p27Kip1 is found in many types of cancers, and decreased expression of p27Kip1 appears to be a poor prognostic factor in several tumor models, including carcinomas of the lung, breast, colorectal, and prostate. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Monkey 
1 ml more info 
14 days 
€361,40 Add to cart -
p27/Kip1 [DCS-72.F6]
Description p27Kip1 is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27Kip1 binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitination and degradation of p27Kip1, while phosphorylation by hKIS on S10 signals nuclear export to the cytoplasm. The expression level of p27Kip1 is high in normal cells. Downregulation of p27Kip1 is found in many types of cancers, and decreased expression of p27Kip1 appears to be a poor prognostic factor in several tumor models, including carcinomas of the lung, breast, colorectal, and prostate. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Monkey
7 ml more info 14 days
€187,20 Add to cart -
PCNA [PC10]
Description Proliferating cell nuclear antigen (PCNA) is a DNA polymerase accessory factor that is required for DNA replication during S phase of the cell cycle and for resynthesis during nucleotide excision repair of damaged DNA. The PCNA antibody detects proliferating cells in both normal and tumor cells. Anti-PCNA labeling index has been shown to be associated with tumor prognosis. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat, Chicken, Zebrafish, Drosophila melanogaster, Yeast
1 ml more info 14 days
€361,40 Add to cart -
PCNA [PC10]
Description Proliferating cell nuclear antigen (PCNA) is a DNA polymerase accessory factor that is required for DNA replication during S phase of the cell cycle and for resynthesis during nucleotide excision repair of damaged DNA. The PCNA antibody detects proliferating cells in both normal and tumor cells. Anti-PCNA labeling index has been shown to be associated with tumor prognosis. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey,Pig (Porcine), Mouse, Rat, Chicken, Zebrafish, Drosophila melanogaster, Yeast
7 ml more info 14 days
€187,20 Add to cart -
Transglutaminase II [TGM2/419]
Description Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Rabbit, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Transglutaminase II [TGM2/419]
Description Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Monkey, Rabbit, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart
