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Article number: MC0347

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TDP43/TAR DNA binding protein-43 [3H8]

Description	TDP43 or TAR DNA-binding protein 43 belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. It is also is involved in transcriptional regulation and exon splicing. While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease. (Shipping Cost: €200.00)
Host	Mouse
Application	Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat

Article number: MC0103

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Description	It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TYRP-1). It is involved in melanin synthesis. TYRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.ĀRecent evidence suggests that TYRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TYRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. (Shipping Cost: €200.00)
Host	Mouse
Application	Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC)
Reactivity	Human, Mouse

Article number: MF041M

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Description	MedaFluo™ 488 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF041S

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Description	MedaFluo™ 488 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF042M

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Description	MedaFluo™ 550 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF042S

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Description	MedaFluo™ 550 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF043M

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Description	MedaFluo™ 594 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF043S

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Description	MedaFluo™ 594 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF044M

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Description	MedaFluo™ 650 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat

Article number: MF044S

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Description	MedaFluo™ 650 Immunofluorescence Rabbit Detection Kit (Shipping Cost: €200.00)
Host	Rabbit
Reactivity	Human, Mouse, Goat