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Interferon gamma (IFNG) [MD180R]
Description Interferon-gamma (IFNG) is a potent multifunctional cytokine secreted primarily by activated lymphocytes such as CD4 T helper type 1 (Th1) cells and CD8 cytotoxic T cells, NK cells, B cells, and antigen-presenting cells.. Originally characterized based on anti-viral activities, IFN-gamma also exerts anti-proliferative, immunoregulatory, and proinflammatory activities. IFN-gamma can upregulate MHC class I and II antigen expression by antigen-presenting cells. IFNG expression is induced by mitogens and cytokines. The downstream target genes of IFNG signaling pathway regulate several biological functions, including cell cycle, apoptosis, and inflammation. In adaptive immunity, IFNG directly regulates the differentiation, activation, and homeostasis of Th1 cells; inhibits Th2 cell development; promotes regulatory T cell development and natural killer cell activity. This antibody recognizes a human interferon protein of 20-25kDa, and both recombinant and native human IFNG. It is specific to Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€214,50 Add to cart -
IRAK2 Polyclonal
Description IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€494,00 Add to cart -
IRAK2 Polyclonal
Description IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
IRTA1/FCRL4 Polyclonal
Description Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue.May function as an inhibitor of the B-cell receptor signaling and in the B-cell-mediated immune response. (Shipping Cost: €200.00) Host Rabbit Application Peptide ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€388,70 Add to cart -
JMJD2C/KDM4C Polyclonal
Description JMJD2C (jumonji domain containing 2C), also known as KDM4C, GASC1, JHDM3C ,or Lysine-specific demethylase 4C, is a nuclear protein that belongs to the Jumonji domain 2 (JMJD2) family of histone demethylases. Jmjd2c is an ubiquitously expressed histone demethylase that specifically demethylates Lys-9 and Lys-36 residues of histone H3. Functioning as a trimethylation-specific demethylase, JMJD2C demethylates specific lysine residues of Histone H3, thereby converting the trimethylated Histone H3 to its dimethylated form and playing a central role in the histone code. Through its ability to modify histones, JMJD2C increases the rate of cell proliferation and promotes the expression of a variety of proteins. JMJD2C binds iron as a cofactor and contains two Tudor domains through which it interacts with methylated histones. Overexpression of JMJD2C is associated with esophageal squamous cell carcinoma, suggesting a possible role for JMJD2C in carcinogenesis. Two isoforms of JMJD2C exist due t Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€455,00 Add to cart -
Kappa Light Chain [MD137R]
Description Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda. The gene rearrangement process that generates the immunoglobulin molecule results in either a productive kappa gene or a productive lambda gene. The mechanics of the rearrangement process normally produce approximately twice as many kappa-bearing cells as lambda. However this ratio loses during malignant transformation. The kappa light chain antibody labels kappa light chain expressing B lymphocytes and plasma cells. Other cells may also express kappa light chain due to nonspecific uptake of immunoglobulin. Individual B cells express either kappa or lambda light chains. Monoclonality is generally assumed to be evidence of a malignant proliferation. Paired with lambda, kappa light chain is useful in identifying monoclonality of lymphoid malignancies. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Kappa Light Chain [MD137R]
Description Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda. The gene rearrangement process that generates the immunoglobulin molecule results in either a productive kappa gene or a productive lambda gene. The mechanics of the rearrangement process normally produce approximately twice as many kappa-bearing cells as lambda. However this ratio loses during malignant transformation. The kappa light chain antibody labels kappa light chain expressing B lymphocytes and plasma cells. Other cells may also express kappa light chain due to nonspecific uptake of immunoglobulin. Individual B cells express either kappa or lambda light chains. Monoclonality is generally assumed to be evidence of a malignant proliferation. Paired with lambda, kappa light chain is useful in identifying monoclonality of lymphoid malignancies. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
Ki67 [SP6]
Description The antibody labels Ki-67, a proliferation-associated nuclear protein expressed during all active phases of the cell cycle. Quantitative determination of the fraction of cells which stain positive for the Ki-67 nuclear antigen has been demonstrated to be a highly accurate way of assessing the fraction of proliferating cells within a given tissue. Estimation of the cell proliferation index in tumor cells is valuable as a prognostic indicator. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Common Marmoset
1 ml more info 14 days
€416,00 Add to cart -
Ki67 [SP6]
Description The antibody labels Ki-67, a proliferation-associated nuclear protein expressed during all active phases of the cell cycle. Quantitative determination of the fraction of cells which stain positive for the Ki-67 nuclear antigen has been demonstrated to be a highly accurate way of assessing the fraction of proliferating cells within a given tissue. Estimation of the cell proliferation index in tumor cells is valuable as a prognostic indicator. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Common Marmoset
7 ml more info 14 days
€254,80 Add to cart -
KRAS Polyclonal
Description This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. (Shipping Cost: €200.00) Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart
