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Cyclin D1 [DCS-6]
Description Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€361,40 Add to cart -
Cyclin D1 [DCS-6]
Description Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Cyclin D2 [DCS-3]
Description The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition, while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl-1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Cyclin D2 [DCS-3]
Description The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition, while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl-1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€254,80 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [139H2]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [139H2]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [SPM492]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
EMA/CA15.3/MUC1/Episialin/CD227 [SPM492]
Description Mucins are a family of heavily glycosylated high molecular weight glycoproteins. Total 21 mucins have been identified to date. Mucins are well known for its involvement in the protection and lubrication of luminal epithelial surfaces. MUC1, a transmembrane mucins, has been shown to be involved in several signaling pathways, including Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. When MUC1 forms a complex with beta-catenin, it enters the nucleus to activate T-cell factor/leukocyte enhancing factor 1 transcription factors and gene expression. In addition, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. MUC1 is expressed in many types of epithelial cell in gastrointerstinal tract, lung, breast, pancreas and genitourinary tract. MUC1 is also detected in activated and unactivated T-cells. In some tumors derived from epithelial cells, MUC1 expression is associated with tumor type and invasiv Host Mouse Application ELISA, Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
Enigma/PDLIM1 [MD100]
Description PDLIM1 (PDZ and LIM domain 1), also known as Enigma, CLIM1, CLP36, or Elfin, is a 329 amino acid cytoplasmic protein that associates with actin stress fibers at the cytoskeleton. This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. Expressed at high levels in skeletal muscle and heart and at lower levels in colon, small intestine, spleen, lung, placenta, kidney, liver, thymus and pancreas, especially PDLIM1 functions as a cytoskeletal protein that is thought to act as an adaptor, bringing target proteins to the cytoskeleton. The protein has a role in cell migration, invasion and metastasis in breast cancer. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
EZH2/KMT6 [6G4F4]
Description EZH2 (enhancer of zeste homologue 2) or KMT6 or Enx1, is a polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. EZH2 and BMI-1 genes are coexpressed in Reed-Sternberg cells of Hodgkin’s disease. Coexpression of BMI-1 and EZH2 is also associated with cycling cells and degree of malignancy in B-cell non-Hogkin’s lymphoma. It is involved in the progression of prostate cancer, and has been identified as a marker of aggressive breast cancer. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€520,00 Add to cart
