| Quantity | Title | Price |
|---|---|---|
| 1 × | Biotin anti-human CD193 (CCR3) | €123,00 |
| 1 × | PE anti-mouse CD309 (VEGFR2, Flk-1) | €61,50 |
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Moesin [MSN491]
Description The ezrin, radixin and moesin (ERM) proteins function as linkers between the plasma membrane and the actin cytoskeleton and are involved in cell adhesion, membrane ruffling and microvilli formation. ERM proteins undergo intra or intermolecular interaction between their amino- and carboxy-terminal domains, existing as inactive cytosolic monomers or dimers. Phosphorylation at a carboxy-terminal threonine residue (Thr567 of ezrin, Thr564 of radixin, Thr558 of moesin), which disrupts their amino- and carboxy-terminal association, may play a key role in modulating the conformation and function of ERM proteins. Phosphorylation at Thr567 of ezrin is required for cytoskeletal rearrangements and oncogeneinduced transformation. Ezrin is also phosphorylated at tyrosine residues upon growth factor stimulation. Phosphorylation of Tyr353 of ezrin transmits a survival signal during epithelial differentiation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Rat 
7 ml more info 
14 days 
€187,20 Add to cart -
MSH2 [EPR21017-123]
Description MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€464,10 Add to cart -
MSH2 [EPR21017-123]
Description MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
MSH6 [MD179R]
Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
MSH6 [MD179R]
Description The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system. Carriers of the mismatch repair gene mutations have a high lifetime risk of developing Hereditary Non-Polyposis Colon Cancer (HNPCC) and several other cancers including endometrial cancer due to microsatellite instability (MSI) caused by accumulation of DNA replication errors in proliferating cells. MSH6 antibody is useful for screening and diagnosis of patients with MSI. The level of MSI has been reported to be associated with prognosis in colon cancer. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MUC2 [CCP58]
Description Mucins are high molecular weight glycoproteins produced by many epithelial tissues. MUC2 is a member of the mucin protein family. MUC2 is secreted and forms an insoluble mucous barrier that protects the gut lumen. MUC2 is the major secretory glycoprotein specifically expressed in goblet cells of the intestinal and airway epithelium. Its expression is a common feature of all mucinous carcinomas derived from different organs including breast, stomach, colon and prostate where it may act as a potential prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
MUC3 [M3.1]
Description Specificity & Comments It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadl Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MVH/DDX4/VASA [2F9H5]
Description MVH or DDX4 or VASA is a 724 amino acid, ATP-dependent RNA helicase that belongs to the DEAD-box family. MVH is specifically expressed in germline cells throughout the life cycle and is undetectable in somatic tissues. In vertebrates, MVH is restricted to bisexually reproducing organisms. It is cytoplasmic and is present only in migratory primordial germ cells in the region of the gonadal ridge. On testicular sections, MVH expression is the highest in spermatogonia, reduced in spermatocytes, low in spermatids and absent in sperm. In the ovary, MVH expression is the highest in oogonia but persists throughout oogenesis. MVH has a glycine-rich N-terminus with multiple repeats of an RGG motif believed to function in RNA binding. Specifically, it regulates the translation of intricate mRNAs that are essential for differentiation. (Shipping Cost: €200.00) Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB), Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
MyoD1 (Rhabdomyosarcoma Marker) [5.8A]
Description Recognizes a phosphor-protein of 45kDa, identified as MyoD1. The epitope of this antibody maps between amino acid 180-189 in the C-terminal of mouse MyoD1 protein. It does not cross react with myogenin, Myf5, or Myf6. Antibody to MyoD1 labels the nuclei of myoblasts in developing muscle tissues. MyoD1 is not detected in normal adult tissue, but is highly expressed in the tumor cell nuclei of rhabdomyosarcomas. Occasionally nuclear expression of MyoD1 is seen in ectomesenchymoma and a subset of Wilm s tumors. Weak cytoplasmic staining is observed in several non-muscle tissues, including glandular epithelium and also in rhabdomyosarcomas, neuroblastomas, Ewing s sarcomas and alveolar soft part sarcomas. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse, Rat, Chicken
1 ml more info 14 days
€361,40 Add to cart
