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MSH2 [EPR21017-123]
Product group: | Primary |
Monoclonal/ Polyclonal: | Monoclonal |
Clone: | RED2 equivalent to EPR21017-123 |
Host: | Rabbit |
Isotype: | IgG |
Application: | Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Application notes: | 100-500 |
Conjugation Type: | Unconjugated |
Reactivity: | Human |
General notes: | Localization: nucleus. |
Buffer: | Tris EDTA pH9.0 |
UNSPSC code: | 12352203 |
MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas. (Shipping Cost: €200.00)
MSH2 [EPR21017-123]
MutS homologue 2 (MSH2) is a DNA mismatch repair protein that belongs to the MutS family. MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3), which bind to DNA mismatches thereby initiating DNA repair. Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6. MutS alpha may also play a role in DNA homologous recombination repair. MSH2 is found in normal cells. Loss of MSH2 is linked to hereditarynonpolyposis colorectal cancer (HNPCC) and MSI-positive endometrial and ovarian cancers. Immunohistochemical analysis of MSH2 expression has been reported to be a practical and reliable method for the routine detection of the vast majority of MSI-H colorectal adenocarcinomas.
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