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Cytokeratin Basic [AE3]
Description Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50’, 48, 46, 45, and 40kDa. The basic keratin s have molecular weights of 65-67, 64, 59, 58, 56 and 52kDa. Members of acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with cell type, differentiation status and environment. Many studies have shown the us efulness of keratins as markers in cancer research and tumor diagnosis. AE1 labels most acidic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. AE1 is particularly suited to distinguish poorly differentiat ed carcinomas from non-epithelial neoplasms. This marker stains both normal and neoplastic cells of epithelial origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken 
7 ml more info 
14 days 
€187,20 Add to cart -
Cytokeratin HMW [34BE12]
Description The antibody reacts with keratins 1,5,10, and 14. In normal tissue, the antibody labels squamous, ductal, and other complex epithelia. The antibody has variable positivity to adenocarcinomas. The most useful application of the antibody was described in the differential diagnosis of basal cell hyperplasia and atypical adenomatous hyperplasia of the prostate. The antibody labels benign basal cells of prostate acinibut not prostate adenocarcinoma. In thyroid neoplasm, positivity was reported to be confined to papillary carcinoma, whereas follicular neoplasms are negative. This antibody, when incorporated into a panel of antibodies, aids in the differrential diagnosis of anaplastic tumors of unknown origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
Cytokeratin HMW [34BE12]
Description The antibody reacts with keratins 1,5,10, and 14. In normal tissue, the antibody labels squamous, ductal, and other complex epithelia. The antibody has variable positivity to adenocarcinomas. The most useful application of the antibody was described in the differential diagnosis of basal cell hyperplasia and atypical adenomatous hyperplasia of the prostate. The antibody labels benign basal cells of prostate acinibut not prostate adenocarcinoma. In thyroid neoplasm, positivity was reported to be confined to papillary carcinoma, whereas follicular neoplasms are negative. This antibody, when incorporated into a panel of antibodies, aids in the differrential diagnosis of anaplastic tumors of unknown origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
Cytokeratin LMW [KRTL/1077]
Description Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.This antibody recognizes low molecular weight cytokeratins (CK 10 (56.5), CK14 (50), CK15 (50), CK16 (48) and CK19(40) of the acidic family. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) (0.5-1ug/ml) Reactivity Human, Rat
1 ml more info 14 days
€361,40 Add to cart -
Cytokeratin LMW [KRTL/1077]
Description Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.This antibody recognizes low molecular weight cytokeratins (CK 10 (56.5), CK14 (50), CK15 (50), CK16 (48) and CK19(40) of the acidic family. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) (0.5-1ug/ml) Reactivity Human, Rat
7 ml more info 14 days
€187,20 Add to cart -
Desmocollin-1/DSC1 [A4]
Description Desmocollin-1, also known as Cadherin family member 1 (CDHF1), is encoded by the DSC1 gene in human. Desmocollin-1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Desmocollins, along with the desmogleins, are found primarily in epithelial cells where they constitute the desmosomes, a type of cell junction required for cell adhesion. Desmocollins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmocollin interaction with intermediate filaments. The DSC1 gene comprises 17 exons spanning approximately 33 kb on 18q12.1, and the DSC3 gene comprises 17 exons spanning approximately 49 kb on 18q12.1. Alternative splicing gives rise to two DSC1 and DSC3 isoforms, designated 1A and 1B, and 3A and 3B, r Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Desmocollin-1/DSC1 [A4]
Description Desmocollin-1, also known as Cadherin family member 1 (CDHF1), is encoded by the DSC1 gene in human. Desmocollin-1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Desmocollins, along with the desmogleins, are found primarily in epithelial cells where they constitute the desmosomes, a type of cell junction required for cell adhesion. Desmocollins contain an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The extracellular domain mediates intercellular interactions in the desmosome whereas the intracellular domain mediates Desmocollin interaction with intermediate filaments. The DSC1 gene comprises 17 exons spanning approximately 33 kb on 18q12.1, and the DSC3 gene comprises 17 exons spanning approximately 49 kb on 18q12.1. Alternative splicing gives rise to two DSC1 and DSC3 isoforms, designated 1A and 1B, and 3A and 3B, r Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
EGFR [GFR/1667]
Description Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation. Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal of EGFR. Autophosphorylation of Tyr 992 creates a binding site for the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling. In breast cancer, EGFR is predorminately expressed in basal cell-like carcinoma, it has been recommendated for identification of basal-like breast carcinoma along with Cytokeratin 5/6. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
EGFR [GFR/1667]
Description Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, activated by epidermal growth factor (EGF), affects cell growth and differentiation. Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. Phosphorylation of Tyr 992, Tyr 1068 and Tyr 1086 is required for conformational change in the C-terminal of EGFR. Autophosphorylation of Tyr 992 creates a binding site for the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling. In breast cancer, EGFR is predorminately expressed in basal cell-like carcinoma, it has been recommendated for identification of basal-like breast carcinoma along with Cytokeratin 5/6. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
EMI1 (Early Mitotic Inhibitor-1) [EMI1/1176]
Description It recognizes a 56kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart
