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HTLV-1 Tax [1A3]
Description The Human T-lymphotropic virus Type I (HTLV-1) is a human RNA retrovirus that causes T-cell leukemia/lymphoma (ATL) in adults and may also be involved in certain demyelinating diseases, including tropical spastic paraparesis. The HTLV-1 genome is diploid, composed of two copies of a single-stranded RNA virus whose genome is copied into a double-stranded DNA form that integrates into the host cell genome, at which point the virus is referred to as a provirus. The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-tr Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity HTLV-1 
7 ml more info 
14 days 
€174,20 Add to cart -
IDL/Intermediate density lipoprotein Polyclonal
Description Intermediate-density lipoproteins (IDLs) belong to the lipoprotein particle family and are formed from the degradation of very low-density lipoproteins. IDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, IDL, LDL, HDL) that enable fats and cholesterol to move within the water-based solution of the bloodstream. Each native IDL particle consists of protein that encircles various lipids, enabling, as a water-soluble particle, these lipids to travel in the aqueous blood environment as part of the fat transport system within the body. Their size is, in general, 25 to 35 nm in diameter, and they contain primarily a range of triacylglycerols and cholesterol esters. They are cleared from the plasma into the liver by receptor-mediated endocytosis, or further degraded to form LDL particles. In general, IDL, somewhat similar to low-density lipoprotein (LDL), transports a variety of triglyceride fats and cholesterol and, like LDL, can also promote the growth of atheroma. (Sh Host Mouse Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human 
1 ml more info 14 days
€494,00 Add to cart -
IgG Gamma Polyclonal
Description Representing approximately 75% of serum immunoglobulins in humans, IgG is the most abundant antibody isotype found in the circulation. IgG molecules are synthesized and secreted by plasma B cells. IgG antibody reacts with the IgG human immunoglobulin gamma-chain. The antibody marks IgG contained in all plasma cells and their precursors, most of them follicular dendritic cells, centroblastic-centrocytic lymph cells and IgG secretory multiple myelomas. Generally, membrane bond immunoglobulins, connective tissue or blood vessels bond extracellular immunoglobulins and immunocomplex can only be shown on frozen tissues. Plasma cells may not be much stained on frozen tissues because immunoglobulins distribute diffusely by their cytoplasm. Anti-Human IgG gamma antibody is research for immunology, microbiology, and cancer. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
INSM1 [A8]
Description Insulinoma-associated 1 or INSM1/IA1 is a zinc-finger transcription factor restrictedly expressed in pancreatic β-cells during early pancreas development. INSM1/IA1 regulates NeruoD1/β2 and insulin gene expression during β-cell maturation. INSM1 transcription factor, an important player in early embryonic neurogenesis, contributes to endocrine and neuroendocrine cell differentiation. INSM1 is expressed transiently in embryonic neuroendocrine (NE) tissue, thought to coordinate termination of cell division with differentiation of NE and neuroepithelial cells. In adult tissues, INSM1 has been identified in multiple tumors of NE or neuroepithelial origin and might be a potential neoplastic marker. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
INSM1 [A8]
Description Insulinoma-associated 1 or INSM1/IA1 is a zinc-finger transcription factor restrictedly expressed in pancreatic β-cells during early pancreas development. INSM1/IA1 regulates NeruoD1/β2 and insulin gene expression during β-cell maturation. INSM1 transcription factor, an important player in early embryonic neurogenesis, contributes to endocrine and neuroendocrine cell differentiation. INSM1 is expressed transiently in embryonic neuroendocrine (NE) tissue, thought to coordinate termination of cell division with differentiation of NE and neuroepithelial cells. In adult tissues, INSM1 has been identified in multiple tumors of NE or neuroepithelial origin and might be a potential neoplastic marker. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
Internexin Alpha/NF66 [2E3]
Description Alpha–internexin is an intermediate filament family member expressed during early neuron development and is related to the neurofilament proteins NF-H, NF-L and NF-M. Due to the specific spatial and temporal expression pattern of alpha-internexin, it is a useful marker of neuronal subtypes. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed in large amounts early in neuronal development, but is downregulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. The very early developmental expression of alpha-internexin means its pr Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Mouse, Cat, Rabbit, Bovine, Pig
1 ml more info 14 days
€374,40 Add to cart -
Internexin Alpha/NF66 [2E3]
Description Alpha–internexin is an intermediate filament family member expressed during early neuron development and is related to the neurofilament proteins NF-H, NF-L and NF-M. Due to the specific spatial and temporal expression pattern of alpha-internexin, it is a useful marker of neuronal subtypes. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed in large amounts early in neuronal development, but is downregulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. The very early developmental expression of alpha-internexin means its pr Host Mouse Application ELISA, Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Rat, Mouse, Cat, Rabbit, Bovine, Pig
7 ml more info 14 days
€187,20 Add to cart -
IRAK2 Polyclonal
Description IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€494,00 Add to cart -
IRAK2 Polyclonal
Description IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B. (Shipping Cost: €200.00) Host Rabbit Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€201,50 Add to cart -
Ki67 [MDKI67]
Description The antibody labels Ki-67, a proliferation-associated nuclear protein expressed during all active phases of the cell cycle. Quantitative determination of the fraction of cells which stain positive for the Ki-67 nuclear antigen has been demonstrated to be a highly accurate way of assessing the fraction of proliferating cells within a given tissue. Estimation of the cell proliferation index in tumor cells is valuable as a prognostic indicator. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart
