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HTLV-1 Tax [1A3]
| Product group: | Primary |
| Monoclonal/ Polyclonal: | Monoclonal |
| Clone: | 1A3 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Application: | ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) |
| Application notes: | Prediluted |
| Conjugation Type: | Unconjugated |
| Reactivity: | HTLV-1 |
| General notes: | Localization: Expressed Tax protein in HTLV-1 infected tissue. |
| UNSPSC code: | 12352203 |
The Human T-lymphotropic virus Type I (HTLV-1) is a human RNA retrovirus that causes T-cell leukemia/lymphoma (ATL) in adults and may also be involved in certain demyelinating diseases, including tropical spastic paraparesis. The HTLV-1 genome is diploid, composed of two copies of a single-stranded RNA virus whose genome is copied into a double-stranded DNA form that integrates into the host cell genome, at which point the virus is referred to as a provirus. The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-tr
HTLV-1 Tax (1A3)
The Human T-lymphotropic virus Type I (HTLV-1) is a human RNA retrovirus that causes T-cell leukemia/lymphoma (ATL) in adults and may also be involved in certain demyelinating diseases, including tropical spastic paraparesis. The HTLV-1 genome is diploid, composed of two copies of a single-stranded RNA virus whose genome is copied into a double-stranded DNA form that integrates into the host cell genome, at which point the virus is referred to as a provirus. The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including the CREB/ATF and NFkB pathways. In addition, Tax deregulates the expression of downstream genes, which mediate cell cycle control.
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