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  • Article number: AS-24175
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    FITC-LC-Antennapedia Peptide

    Description The Antennapedia homeodomain protein of Drosophila has the ability to penetrate biological membranes and the third helix of this protein, residues 43-58, known as penetratin (RQIKIWFQNRRMKWKK-amide) has the same translocating properties as the entire protein. | This is a fluorescent (FITC)-labeled Antennapedia, Abs/Em = 493/522 nm. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €162,00 
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  • Article number: AS-60253-05
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    Amylin (1-37), rat, mouse

    Description Rat/mouse Amylin differs from the human version in 6 amino acids: H18R, F23L, A25P, I26V, S28P and S29P (first letter is the amino acid of the human sequence). Unlike the human IAPP (Amylin), rat Amylin does not form amyloid fibers. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €309,00 
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  • Article number: AS-24235-
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    Beta-Amyloid (1-40) Peptide

    Description Aß (1-40) together with Aß (1-42) are two major C-terminal variants of the Aß protein constituting the majority of Aßs. These undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain. | Electron microscopy of b-amyloid (1-40) stained with Thioflavin T (data generated by an AnaSpec scientist). (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €134,00 
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  • Article number: AS-20651
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    Atrial Natriuretic Peptide (1-28), rat

    Description A-type (Atrial) natriuretic peptide (ANP), also called Cardiodilatine (CDD), is a peptide hormone composed of 28 amino acids. It is processed from a 151aa prepro-ANP by signal peptide removal, followed by specific protease cleavage by corin of the pro-ANP. The 28a C-terminal peptide hormone contains a 17aa ring formed by a disulfide bridge between Cys7 and Cys23. and a tail. It is produced in cardiac myocytes, where it exerts vasodilating effects, hence playing an important role in the regulation of blood pressure and natriuresis/diuresis. Residues Phe8, Arg14 and the C-terminal sequence of ANP are known to bind to human NPR-A (Natriuretic peptide receptor type A). ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which share a similar ring structure. | Rat ANP differs from the human hormone by only one residue at position 12. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €122,00 
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  • Article number: AS-24231
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    Beta-Amyloid (1-28) Peptide

    Description The three-dimensional solution structure of Aß (1-28) reveals the folding of the peptide to form a predominantly a-helical structure with a bend centered at residue 12 and the side chains of histidine-13 and lysine-16 in close proximity, residing on the same face of the helix. Their proximity may constitute a binding motif with the heparan sulfate proteoglycans. Aß (1-28) is highly hydrophilic and shares sequences with bA4, the major component of Aß. Its assembly is fibrillar, i.e., elongated in a single direction. Reports show that synthetic peptides Aß (1-40) and Aß (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €105,00 
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  • Article number: AS-24229
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    Beta-Amyloid (12-28) Peptide

    Description Aβ (12-28) represents a binding site for apolipoprotein E (apoE). ApoE is a genetically inherited risk factor for Alzheimer’s disease that promotes aggregation of toxic Aβ. This sequence encompasses a hydrophobic domain (residues 14–21) and a ß-turn (residues 22–28) which place two hydrophobic domains of Aß 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of Aß peptides into fibrils. The secondary structure of Aß (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of Aß is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of Aß pathology in Alzheimer’s disease (AD). Aß (11-28) and five other fragments enhanced aggregation of full length Aß (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Aß. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €83,00 
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  • Article number: AS-64819-05
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    Protegrin-1 (PG-1), amide

    Description This peptide is Protegrin-1 (PG-1) with a modified C-terminal amide. PG-1 is an 18-amino-acid beta-hairpin antimicrobial peptide found in porcine leukocytes and belongs to the cathelicidin family. PG-1 exhibits broad-spectrum activity unaffected by extracellular NaCl concentrations and is capable of inactivating numerous bacterial strains, Candida albicans, and some enveloped viruses. The efficacy is strongly dependent upon the existence of two disulfide bonds that stabilize the beta-sheet structure. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €312,00 
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  • Article number: AS-27275
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    Beta-Amyloid (42-1)

    Description This peptide corresponds to the CtoN inverted sequence of Beta-amyloid 1-42. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €370,00 
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  • Article number: AS-23513-05
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    Beta-Amyloid (1-40), FAM-labeled

    Description Beta-Amyloid (1-40) together with beta-Amyloid (1-42) are two major C-terminal variants of the beta-Amyloid protein. These beta-Amyloid peptides undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain. This is a fluorescent (FAM)-labeled ß-Amyloid (1-40), Abs/Em=494/521 nm. FAM is preferred over FITC because of its photo- and chemical stability. | 494/521 (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €488,00 
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  • Article number: AS-61483-05
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    Beta-Amyloid (1-40)-Lys(Biotin)-NH2

    Description Beta-Amyloid (1-40) together with beta-Amyloid (1-42) are two major C-terminal variants of the beta-Amyloid protein. These beta-Amyloid peptides undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain. This peptide is biotinylated at the C-terminus. (Shipping Cost: €35.00)
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    Normal leadtime 3 days
    Calculated total €549,00 
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