You are here
-
Osteocalcin/BGLAP [G5]
Description Bone γ-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23 Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains 3 vitamin K-dependent γ-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q22 impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 
14 days 
€361,40 Add to cart -
Osteonectin/SPARC/BM40 [MD18R]
Description Bone matrix consists of collagen and non-collagenous proteins. Osteonectin, a 32-kD calcium-binding glycoprotein, is found in a variety of cell types, which include osteoblastic epithelial cells and fibroblasts. In bone tissue, this glycoprotein is present in active osteoblasts and young osteocytes, and it is involved in the early steps of mineralization of skeletal tissue. Osteonectin is a recognized differentiation marker of normal osteogenic cells.The latter represents about 10% of the total protein content of bone. Osteonectin is one of the non-collagenous components and is bone-specific due to its biochemical properties. Osteonectin is a useful biochemical marker for bone-related tumors. Thus, osteonectin antibody can be used to demonstrate the presence of osteonectin in active osteoblasts and osteoprogenitor cells as well as in young osteocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Osteonectin/SPARC/BM40 [MD18R]
Description Bone matrix consists of collagen and non-collagenous proteins. Osteonectin, a 32-kD calcium-binding glycoprotein, is found in a variety of cell types, which include osteoblastic epithelial cells and fibroblasts. In bone tissue, this glycoprotein is present in active osteoblasts and young osteocytes, and it is involved in the early steps of mineralization of skeletal tissue. Osteonectin is a recognized differentiation marker of normal osteogenic cells.The latter represents about 10% of the total protein content of bone. Osteonectin is one of the non-collagenous components and is bone-specific due to its biochemical properties. Osteonectin is a useful biochemical marker for bone-related tumors. Thus, osteonectin antibody can be used to demonstrate the presence of osteonectin in active osteoblasts and osteoprogenitor cells as well as in young osteocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Osteopontin (EPR21139-316]
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
Osteopontin (EPR21139-316]
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€374,40 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€174,20 Add to cart -
OTK4/FKBP1B/FKBP12.6 [H8]
Description Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBPtype PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat, equine, Dog (Canine), Bovine, Pig
1 ml more info 14 days
€361,40 Add to cart -
p120 Catenin [MD153R]
Description Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is a member of this Armadillo gene family of junctional plaque proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Cytoplasmic accumulation of p120 Catenin has been observed in lung cancer, pancreatic cancer, gastric cancer and colon cancers and is associated with poor progress in colon cancer patients. In breast lobular neoplasia, p120 Catenin shows a diffuse cytoplasmic immunostaining pattern, while breast ductal neoplasia retains the membrane immunostaining pattern. p120 Catenin is useful in differentiation of lobular carcinoma from ductal carcinoma of the breast and in identifying early lesions of lobular neoplasia (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
p120 Catenin [MD153R]
Description Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is a member of this Armadillo gene family of junctional plaque proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Cytoplasmic accumulation of p120 Catenin has been observed in lung cancer, pancreatic cancer, gastric cancer and colon cancers and is associated with poor progress in colon cancer patients. In breast lobular neoplasia, p120 Catenin shows a diffuse cytoplasmic immunostaining pattern, while breast ductal neoplasia retains the membrane immunostaining pattern. p120 Catenin is useful in differentiation of lobular carcinoma from ductal carcinoma of the breast and in identifying early lesions of lobular neoplasia (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€214,50 Add to cart
