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CD50 (ICAM-3) [186-2G9]
Description CD50 (ICAM-3) is a leukocyte-specific surface receptor involved in primary immune responses. It belongs to the immunoglobulin gene superfamily (Igsf). CD50 is constitutively expressed on human leukocytes, such as T and B lymphocytes, monocytes and neutrophils, and localizes to the rear of polarized leukocytes and clusters with the ezrin-radixin-moesin (ERM) proteins moesin and ezrin. These ERM proteins link CD50 to the actin cytoskeleton. It recognizes the Beta 2-integrin leukocyte function associated molecule-1 (LFA-1) as a receptor, moreover it also functions as a ligand for LFA-1, Mac-1 (CD11b/CD8), adb2 integrins, and the Dendritic Cell-Specific ICAM-3-Grabbing Non Integrin (DC-SIGN) C-type lectin. CD50 mediates a plethora of immunologically relevant homotypic and heterotypic intercellular interactions, such as leukocyte recruitment during migration, removal of apoptotic cells and lymphocyte interactions with antigen-presenting cells. Importantly, CD50 is involved in the interactio Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€361,40 Add to cart -
CD50 (ICAM-3) [186-2G9]
Description CD50 (ICAM-3) is a leukocyte-specific surface receptor involved in primary immune responses. It belongs to the immunoglobulin gene superfamily (Igsf). CD50 is constitutively expressed on human leukocytes, such as T and B lymphocytes, monocytes and neutrophils, and localizes to the rear of polarized leukocytes and clusters with the ezrin-radixin-moesin (ERM) proteins moesin and ezrin. These ERM proteins link CD50 to the actin cytoskeleton. It recognizes the Beta 2-integrin leukocyte function associated molecule-1 (LFA-1) as a receptor, moreover it also functions as a ligand for LFA-1, Mac-1 (CD11b/CD8), adb2 integrins, and the Dendritic Cell-Specific ICAM-3-Grabbing Non Integrin (DC-SIGN) C-type lectin. CD50 mediates a plethora of immunologically relevant homotypic and heterotypic intercellular interactions, such as leukocyte recruitment during migration, removal of apoptotic cells and lymphocyte interactions with antigen-presenting cells. Importantly, CD50 is involved in the interactio Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD52 [CD52/2276R]
Description CD52 is a small (25-29 kDa), heavily glycosylated peptide that is bound to the cell surface membrane by a GPI link. Also known as CAMPATH-1, CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable. CD52 is an ideal target for therapeutic agents involved in the treatment of B cell malignancies and autoimmune diseases including rheumatoid arthritis and multiple sclerosis. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Monkey
1 ml more info 14 days
€416,00 Add to cart -
CD52 [CD52/2276R]
Description CD52 is a small (25-29 kDa), heavily glycosylated peptide that is bound to the cell surface membrane by a GPI link. Also known as CAMPATH-1, CD52 is expressed at high density by lymphocytes, monocytes, eosinophils, thymocytes and macrophages. It is expressed by most lymphoid derived malignancies, although expression on myeloma cells is variable. CD52 is an ideal target for therapeutic agents involved in the treatment of B cell malignancies and autoimmune diseases including rheumatoid arthritis and multiple sclerosis. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human, Monkey
7 ml more info 14 days
€234,00 Add to cart -
CD54 [1H4]
Description ICAM-1 (intercellular adhesion molecule) has 7 potential N-linked glycosylation sites. It is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
CD56/SCLC/NCAM [123C3]
Description Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule which is glycosylated or sialylated to produce the mature species . NCAM (CD56) is reported to express on most neuroectodermal derived cell lines, tissues, and neoplasms such as retinoblastoma, medullblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
CD56/SCLC/NCAM [123C3]
Description Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule which is glycosylated or sialylated to produce the mature species . NCAM (CD56) is reported to express on most neuroectodermal derived cell lines, tissues, and neoplasms such as retinoblastoma, medullblastoma, astrocytoma, and neuroblastoma. It is also expressed on some mesodermally derived tumors such as rhabdomyosarcoma and also on natural killer cells. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Reactivity Human, Rat
7 ml more info 14 days
€187,20 Add to cart -
CD57/B3GAT1 [NK-1]
Description CD57 is expressed on a natural killer (NK) cell subset, T cell subset, brain, neuroectodermal tumors, small cell lung carcinoma, prostate carcinomas, nerve sheath tissue s and their tumor counterparts. In a panel of antibody, the anti -CD57 antibody may be useful for the identification of T-cell large granular lymphocyte disorders, oligodendrogliomas, and neuroendocrine tumors. CD57 may a ssist in the identification of lymph ocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin’s disease. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
CD57/B3GAT1 [NK-1]
Description CD57 is expressed on a natural killer (NK) cell subset, T cell subset, brain, neuroectodermal tumors, small cell lung carcinoma, prostate carcinomas, nerve sheath tissue s and their tumor counterparts. In a panel of antibody, the anti -CD57 antibody may be useful for the identification of T-cell large granular lymphocyte disorders, oligodendrogliomas, and neuroendocrine tumors. CD57 may a ssist in the identification of lymph ocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin’s disease. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
CD59/Complement Regulatory Protein/Protectin [SPM616]
Description Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunohistochemistry (IHC),Immunocytochemistry (ICC)/IF Reactivity Human
1 ml more info 14 days
€361,40 Add to cart
