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BRCA1 Protein [MS110]
Description The BRCA-1 gene codes for a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The normal gene plays a role in repairing breaks in DNA. If a mutation occurs in this gene the repair function may become disabled thus leading to more DNA replication errors and neoplastic growth. Current findings suggest that BRCA-1 may play an as yet undefined protective role in cells, as it is strongly expressed in epithelial cells undergoing high levels of proliferation in association with differentiation. Additional findings have det ermined that complete loss of BRCA-1 nuclear expression in breast cancer and the correlation with poor prognostic markers imply that the altered BRCA-1 phenotype may provide an added prognostic parameter for breast cancer and could be applied for a potential rapid screening technique to identify BRCA-1 mutations (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
BRCA1-associated Protein 1 (BAP1) [C4]
Description The BRCA-1 gene codes for a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The normal gene plays a role in repairing breaks in DNA. If a mutation occurs in this gene the repair function may become disabled thus leading to more DNA replication errors and neoplastic growth. Current findings suggest that BRCA-1 may play an as yet undefined protective role in cells, as it is strongly expressed in epithelial cells undergoing high levels of proliferation in association with differentiation. Additional findings have det ermined that complete loss of BRCA-1 nuclear expression in breast cancer and the correlation with poor prognostic markers imply that the altered BRCA-1 phenotype may provide an added prognostic parameter for breast cancer and could be applied for a potential rapid screening technique to identify BRCA-1 mutations (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
BRCA1-associated Protein 1 (BAP1) [MD121R]
Description The BRCA-1 gene codes for a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The normal gene plays a role in repairing breaks in DNA. If a mutation occurs in this gene the repair function may become disabled thus leading to more DNA replication errors and neoplastic growth. Current findings suggest that BRCA-1 may play an as yet undefined protective role in cells, as it is strongly expressed in epithelial cells undergoing high levels of proliferation in association with differentiation. Additional findings have det ermined that complete loss of BRCA-1 nuclear expression in breast cancer and the correlation with poor prognostic markers imply that the altered BRCA-1 phenotype may provide an added prognostic parameter for breast cancer and could be applied for a potential rapid screening technique to identify BRCA-1 mutations (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
BrdU [BRD3]
Description 5'-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog that, when added to replicating cells, is incorporated into newly synthesized DNA strands. Evaluating the uptake of BrdU by dividing cells can provide a reliable estimation of cellular proliferation rates. BrdU immunohistochemistry may prove useful in determining proliferative rates for the evaluation of tumors. This antibody is 100% cross-reactive with iododeoxyuridine (IdU). (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
BrdU [BRD3]
Description 5'-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog that, when added to replicating cells, is incorporated into newly synthesized DNA strands. Evaluating the uptake of BrdU by dividing cells can provide a reliable estimation of cellular proliferation rates. BrdU immunohistochemistry may prove useful in determining proliferative rates for the evaluation of tumors. This antibody is 100% cross-reactive with iododeoxyuridine (IdU). (Shipping Cost: €200.00) Host Mouse Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
C1q Polyclonal
Description C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate. Expression of the mRNA, Host Rabbit Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
C1qC [A-12]
Description C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA, as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorde Host Mouse Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
C1qC [A-12]
Description C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA, as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorde Host Mouse Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
C3d Polyclonal
Description Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. It was shown that anti-C3d labeled the epidermal basement membrane in 97% (31/32) cases of bullous pemphigoid (BP), with none of the normal controls demonstrating such findings. In the same study 27% (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 14 days
€374,40 Add to cart -
C3d Polyclonal
Description Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. It was shown that anti-C3d labeled the epidermal basement membrane in 97% (31/32) cases of bullous pemphigoid (BP), with none of the normal controls demonstrating such findings. In the same study 27% (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€174,20 Add to cart
