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CDK4 [EP180]
Description Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a). Overexpression of CDK4 has been observed in many tumor types, including oral squamous cell carcinoma and cancers of the pancreatic (endocrine tumors), lung, breast and colon. The expression of CDK4 is associated with tumor progression. Binh et al. reported a high expression of CDK4 (92%) in atypical lipomatous tumor/well-differentiated liposarcomas (ALT-WDLPS) and dedifferentiated liposarcomas (DDLPS) by immunostaining. CDK4 is useful in differentiating ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€464,10 Add to cart -
CDK4 [EP180]
Description Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a). Overexpression of CDK4 has been observed in many tumor types, including oral squamous cell carcinoma and cancers of the pancreatic (endocrine tumors), lung, breast and colon. The expression of CDK4 is associated with tumor progression. Binh et al. reported a high expression of CDK4 (92%) in atypical lipomatous tumor/well-differentiated liposarcomas (ALT-WDLPS) and dedifferentiated liposarcomas (DDLPS) by immunostaining. CDK4 is useful in differentiating ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
CDX2 [EP25]
Description The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
CDX2 [EP25]
Description The caudal-related homeodomain protein 2, CDX-2, is a transcription factor which is expressed in the intestine and is thought to play an important role in the proliferation and differentiation of intestinal epithelial cells. The CDX-2 protein is expressed in primary and metastatic colorectal carcinomas, intestinal metaplasia of the stomach and intestinal type gastric cancer. In human colorectal cancer, the expression of both CDX2 and carbonic anhydrase 1, a gene regulated by CDX2, is reduced or absent. CDX-2 is one of the important regulators in defining pathways for coordinate control of drug metabolism in the gastrointestinal tract. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart -
Cereblon/CRBN Polyclonal
Description Cereblon or CRBN is a 442 amino acid protein which is highly concentrated in human brain tissue. Cereblon functions energy metabolism, learning and memory. Cereblon acts as a protease in mitochondria and regulates the assembly of KCNT1, as well as the surface expression of KCNT1 in brain regions known to affect memory and learning, such as the hippocampus. The gene encoding Cereblon belongs to a family of ATP-dependent lon proteases that play a role in membrane trafficking and proteolysis. Defects in the Cereblon gene are associated with mild mental retardation. (Shipping Cost: €200.00) Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€494,00 Add to cart -
Chromogranin A [MD87R]
Description Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neurosecretory granules of neuroendocrine cells. Chromogranin A showed broad expression in endocrine tissues including pituitary, adrenal medulla, thyroid, pancreatic islets and gastrointestinal tract. Chromogranin A represents the single most specific marker of neuroendocrine differentiation in general use. It is useful for identification of neuroendocrine tumors. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
Chromogranin A [MD87R]
Description Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neurosecretory granules of neuroendocrine cells. Chromogranin A showed broad expression in endocrine tissues including pituitary, adrenal medulla, thyroid, pancreatic islets and gastrointestinal tract. Chromogranin A represents the single most specific marker of neuroendocrine differentiation in general use. It is useful for identification of neuroendocrine tumors. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
Chromogranin B Polyclonal
Description Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA, Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€163,80 Add to cart -
Claudin 5 [EPR7583]
Description Claudin 5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin 5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin 5 have been found in patients with velocardiofacial syndrome. Claudin 5 labels endothelial cells. It has been used as a marker for endothelial lesions. Claudin 5 is also found in bronchial and lung epithelial cells. In tumors, Claudin 5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€464,10 Add to cart
