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Tau (4-repeat isoform RD4) [1E1/A6]

Description	Tau is a microtubule-associated protein. In adult human brain, 6 tau isoforms are expressed, which are divided into two groups, 3-repeat (3R) and 4-repeat (4R) tau isoforms. Tau assembles into insoluble, filamentous, and hyperphosphorylated inclusions in many neurodegenerative diseases, and different tau isoforms are accumulated in the diseased brains, namely, 6 tau isoforms in AD, 3R tau isoforms in Pick’s disease, and 4R tau isoforms in PSP and CBD. Therfore, isoform-specific tau antibodies are useful tools for immunohistochemical and biochemical studies of tau species in diseased brains. Tau deposited in AD is extensively deamidated at N279. This anti-4R specifically recognizes 4R tau isoforms regardless of deamidation and strongly stained tau in AD brain. (Shipping Cost: €200.00)
Host	Mouse
Application	Immunohistochemistry (IHC), Western Blot (WB)
Reactivity	Human, Mouse, Rat, Bovine

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