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NF-κB p65 [MD35R]
Description Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Monkey, Dog 
1 ml more info 
14 days 
€442,00 Add to cart -
NF-κB p65 [MD35R]
Description Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Hamster, Monkey, Dog
7 ml more info 14 days
€254,80 Add to cart -
NKX2.2 [NX2/294]
Description Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Chicken
1 ml more info 14 days
€361,40 Add to cart -
NKX2.2 [NX2/294]
Description Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Chicken
7 ml more info 14 days
€187,20 Add to cart -
Notch1 [MD36R]
Description Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. (Shipping Cost: €200.00) Host Rabbit Application Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€455,00 Add to cart -
Notch1 [MD36R]
Description Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate. Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes. (Shipping Cost: €200.00) Host Rabbit Application Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€254,80 Add to cart -
NTR3/Sortilin [G11]
Description Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the fulllength NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Osteocalcin/BGLAP [G5]
Description Bone γ-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23 Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains 3 vitamin K-dependent γ-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q22 impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€361,40 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€374,40 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€174,20 Add to cart
