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YAP [63.7]
Description The Yes-associated protein, otherwise known as YAP, is a 14-3-3 binding molecule that was originally recognized by virtue of its ability to bind to the SH3 domain of Yes. The binding of YAP to 14-3-3 requires the phosphorylation of a homologous serine residue (Ser 112) in the YAP 14-3-3 binding motif. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. YAP may link events at the plasma membrane and cytosketeton to inhibition of transcription in the nucleus in a manner regulated by 14-3-3 proteins. YAP shares homology with the WW domain of TAZ, transcriptional co-activator with PDZ binding motif, which functions as a transcriptional co-activator by binding to the PPXY motif present in transcription factors. (Shipping Cost: €200.00) Host Mouse Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
7 ml more info 
14 days 
€187,20 Add to cart -
LOXL2 Polyclonal
Description Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like proteins (LOXL1-4). LOXL2 is an extracellular protein that localizes specifically to sites of elastogenesis. It serves as a cross-linking enzyme, controlling the deposition of elastin and interacts with Fibulin-5. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. Overexpression of LOXL2 has been reported in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that it might play a role in tumor progression. Knockdown of the LOXL2 protein significantly decreases tumor growth. Higher expression has been correlated with metastasis and reduced survival in patients with aggressive breast cancer. LOXL2 Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€494,00 Add to cart -
LOXL2 Polyclonal
Description Lysyl oxidase (LOX) proteins belong to a family of enzymes that oxidize primary amine substrated to reactive aldehydes. LOX is involved in tumor suppression, cell motility, cellular senescence and developmental regulation. There are four homologs of LOX, lysyl oxidase-like proteins, designated LOX-like proteins (LOXL1-4). LOXL2 is an extracellular protein that localizes specifically to sites of elastogenesis. It serves as a cross-linking enzyme, controlling the deposition of elastin and interacts with Fibulin-5. LOXL2 and LOXL3 can interact and cooperate with the Snail protein to downregulate E-cadherin expression. Overexpression of LOXL2 has been reported in a number of cancers and its ability to promote epithelial to mesenchymal transition suggest that it might play a role in tumor progression. Knockdown of the LOXL2 protein significantly decreases tumor growth. Higher expression has been correlated with metastasis and reduced survival in patients with aggressive breast cancer. LOXL2 Host Rabbit Application Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€247,00 Add to cart -
LPA [4H1]
Description The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. (Shipping Cost: €200.00) Host Mouse Application Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat, Sheep, Bovine
1 ml more info 14 days
€572,00 Add to cart
