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Cytokeratin Acid [AE1]
Description Each epithelium contains at least one acidic and one basic keratin. Anti-Cytokeratin clone AE1 labels most acidic keratins and stains most epithelia and their neoplasms. The antibody is suited to distinguish poorly differentiated carcinomas from non-epithelial neoplasms. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken, Turtle -
Cytokeratin Acid [AE1]
Description Each epithelium contains at least one acidic and one basic keratin. Anti-Cytokeratin clone AE1 labels most acidic keratins and stains most epithelia and their neoplasms. The antibody is suited to distinguish poorly differentiated carcinomas from non-epithelial neoplasms. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken, Turtle -
Cytokeratin Basic [AE3]
Description Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50’, 48, 46, 45, and 40kDa. The basic keratin s have molecular weights of 65-67, 64, 59, 58, 56 and 52kDa. Members of acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with cell type, differentiation status and environment. Many studies have shown the us efulness of keratins as markers in cancer research and tumor diagnosis. AE1 labels most acidic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. AE1 is particularly suited to distinguish poorly differentiat ed carcinomas from non-epithelial neoplasms. This marker stains both normal and neoplastic cells of epithelial origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken -
Cytokeratin Basic [AE3]
Description Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights of 56.5, 55, 51, 50, 50’, 48, 46, 45, and 40kDa. The basic keratin s have molecular weights of 65-67, 64, 59, 58, 56 and 52kDa. Members of acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with cell type, differentiation status and environment. Many studies have shown the us efulness of keratins as markers in cancer research and tumor diagnosis. AE1 labels most acidic keratins; therefore, it is a broadly reactive antibody staining most epithelia and their neoplasms. AE1 is particularly suited to distinguish poorly differentiat ed carcinomas from non-epithelial neoplasms. This marker stains both normal and neoplastic cells of epithelial origin. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken -
Cytokeratin Cocktail [AE1&AE3]
Description The antibody cocktail labels simple epithelia and their tumors including cytokeratins expressed in complex stratified squamous epithelia. Positive results aid in the classification of normal and a wide range of neoplastic tissues as epithelial in origin. This antibody serves as first tier antibody for differentiation of undifferentiated neoplasm. Pan Cytokeratin clone AE1/AE3 antibody may be used with a panel of antibodies for differential diagnosis, e.g. Breast vs. lung or liver: CK7, AE1/AE3, CEA, GCDFP-15, TTF-1; Renal vs. lung or liver: AE1/AE3, CEA, TTF-1, Renal Cell Ag; Seminoma vs. lung or liver: CAM5.2, AE1/AE3, PLAP, EMA, CD30; Embryonal germ cell vs. lung or liver: AE1/AE3, TTF-1, CK7, PLAP, CD30. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), (0.5-1ug/million cells), Immunocytochemistry (ICC)/IF (1-2ug/ml), Immunohistochemistry (IHC), Western Blot (WB) (0.5-1ug/ml 2 hrs RT) Reactivity Human, Mouse, Rat, Rabbit, Monkey, Bovine, Dog (Canine), Chicken -
Cytokeratin, pan [PAN-CK (Cocktail)]
Description Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.This antibody recognizes low molecular weight cytokeratins (CK 10 (56.5), CK14 (50), CK15 (50), CK16 (48) and CK19(40) of the acidic family. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken -
Cytokeratin, pan [PAN-CK (Cocktail)]
Description Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1, CK2, CK3, CK4, CK5, CK6, CK7, CK8 and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10, CK12, CK 13, CK14, CK16, CK17, CK18, CK19 and CK20.This antibody recognizes low molecular weight cytokeratins (CK 10 (56.5), CK14 (50), CK15 (50), CK16 (48) and CK19(40) of the acidic family. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Monkey, Bovine, Dog (Canine), Rabbit, Mouse, Rat, Chicken -
Macrophage L1 Protein [MAC387]
Description Recognizes the L1 or Calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. Macrophages usually arise from hematopoietic stem cells in the bone marrow. Under migration into tissues, the monocytes undergo further differentiation to become multifunctional tissue macrophages. They are classified into normal and inflammatory macrophages. Normal macrophages include macrophages in connective tissue (histiocytes), liver (Kupfferā€™s cells), lung (alveolar macrophages), lymph nodes (free and fixed macrophages), spleen (free and fixed macrophages), bone marrow (fixed macrophages), serous fluids (pleural and peritoneal macrophages), skin (histiocytes, Langerhans's cell) and in other tissues. Inflammatory macrophages are present in various exudates. Macrophages are part of the innate immune system, recognizing, engulfing and destroying many potential pathogens including bacteria, Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Baboon, Monkey, Bovine,Pig (Porcine), Goat, Horse, Cat, Dog (Canine), Rabbit, Guinea Pig, Rat, Mouse -
p34/CDC2/CDK1 [POH-1]
Description p34cdc2 is a phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the cell cycle. It is the catalytic subunit of the maturation-promoting factor (MPF) and complexes with both cyclin A and B in mammalian cells. Activated p34cdc2 kinase phosphorylates a variety of substrates leading to some specific events of mitosis including nuclear envelope break-down and chromosome condensation. p34cdc2 has also been implicated in lymphoid proliferation. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine, Monkey -
p34/CDC2/CDK1 [POH-1]
Description p34cdc2 is a phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the cell cycle. It is the catalytic subunit of the maturation-promoting factor (MPF) and complexes with both cyclin A and B in mammalian cells. Activated p34cdc2 kinase phosphorylates a variety of substrates leading to some specific events of mitosis including nuclear envelope break-down and chromosome condensation. p34cdc2 has also been implicated in lymphoid proliferation (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine, Monkey