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CD3 [PC3/188A]
Description CD3 is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell and T helper cells. It is composed of four distinct chains CD3γ, CD3δ, and two CD3ε chains in mammals. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex. CD3 is initially expressed in the cytoplasm of pro-thymocytes, the stem cells from which T-cells arise in the thymus. The pro-thymocytes differentiate into common thymocytes, and then into medullary thymocytes, and it is at this latter stage that CD3 antigen begins to migrate to the cell membrane. The antigen is highly specific marker for T cells, remains present in almost all T-cell lymphomas and leukaemias, and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms. This monoclonal antibody recognizes the epsilon-chain of CD3. C Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat 
7 ml more info 
14 days 
€187,20 Add to cart -
CD31 (PECAM-1) [JC70A]
Description CD31, also known as PECAM-1, is a 130 kDa integral membrane glycoprotein found on the surface of endothelial cells, platelets and some hematopoietic cells. The antibody labels endothelial cells of arteries, arterioles, venules, veins, and non-sinusoidal capillaries in various tissues. CD31 is the most sensitive and specific endothelial cell marker. It is useful for detection of tumors with endothelial origin. In addition, CD31 has been used to identify vascular invasion of tumors, and assessment of angiogenesis which is a prognostic marker for many types of cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Cynomolgus Monkey
1 ml more info 14 days
€361,40 Add to cart -
CD31 (PECAM-1) [JC70A]
Description CD31, also known as PECAM-1, is a 130 kDa integral membrane glycoprotein found on the surface of endothelial cells, platelets and some hematopoietic cells. The antibody labels endothelial cells of arteries, arterioles, venules, veins, and non-sinusoidal capillaries in various tissues. CD31 is the most sensitive and specific endothelial cell marker. It is useful for detection of tumors with endothelial origin. In addition, CD31 has been used to identify vascular invasion of tumors, and assessment of angiogenesis which is a prognostic marker for many types of cancer. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Cynomolgus Monkey
7 ml more info 14 days
€187,20 Add to cart -
CD4 [MT310]
Description CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with an antigen-presenting cell and also interacts directly with MHC class Ⅱ molecules on the surface of the antigen-presenting cells using its extracellular domain. In lymphatic tissues, the CD4+ T-cells are seen in large numbers in the parafollicular zone, while scattered cells are found in the germinal centres and mantle zone. CD4 is also demonstrated in hepatic sinusoidal cells, monocytes and monocytes-derived cells but not expressed on B-cells and immature thymocytes. Precursor T-lymphoblastic lymphomas are therefore variable in their expression of CD4. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory lesions and malignant lymphomas. (Shi Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
1 ml more info 14 days
€374,40 Add to cart -
CD4 [MT310]
Description CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages and dendritic cells. It is a co-receptor that assists the T-cell receptor (TCR) with an antigen-presenting cell and also interacts directly with MHC class Ⅱ molecules on the surface of the antigen-presenting cells using its extracellular domain. In lymphatic tissues, the CD4+ T-cells are seen in large numbers in the parafollicular zone, while scattered cells are found in the germinal centres and mantle zone. CD4 is also demonstrated in hepatic sinusoidal cells, monocytes and monocytes-derived cells but not expressed on B-cells and immature thymocytes. Precursor T-lymphoblastic lymphomas are therefore variable in their expression of CD4. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma. CD4 plays an important role in the classification of lymphocytes in inflammatory lesions and malignant lymphomas. (Shi Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€187,20 Add to cart -
CD47/IAP (Integrin Associated Protein) [CD47/2937]
Description This antibody reacts with Ig domain of CD47 protein. It has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
CD63 [NKI-C3]
Description CD63 is a 53 kDa lysosomal membrane glycoprotein that has been identified as a platelet activation molecule that belongs to the tetraspanin family, which is characterized by the presence of four hydrophobic domains. CD63 can mediate signal transduction events that play a role in the regulation of cellular adhesion, cell differentiation, migration, carcinogenesis and tumor progression. CD63 shows a broad tissue distribution and is predominantly localized in cytoplasmic lysosomes. It is mainly present on platelet lysosomes, granulocytes, basophils and a small percentage of resting T cells, while it is also strongly expressed in early melanoma, breast carcinoma, merkel cell carcinoma, astrocytoma and lung adenocarcinoma. Recent reports also indicate that CD63 is a good prognostic biomarker for human astrocytomas and earlier stages of lung carcinoma. Additionally, CD63 has been useful in differentiating renal oncocytomas (RO) from eosinophilic variants of chromophobe renal cell carcinomas Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
1 ml more info 14 days
€361,40 Add to cart -
CD63 [NKI-C3]
Description CD63 is a 53 kDa lysosomal membrane glycoprotein that has been identified as a platelet activation molecule that belongs to the tetraspanin family, which is characterized by the presence of four hydrophobic domains. CD63 can mediate signal transduction events that play a role in the regulation of cellular adhesion, cell differentiation, migration, carcinogenesis and tumor progression. CD63 shows a broad tissue distribution and is predominantly localized in cytoplasmic lysosomes. It is mainly present on platelet lysosomes, granulocytes, basophils and a small percentage of resting T cells, while it is also strongly expressed in early melanoma, breast carcinoma, merkel cell carcinoma, astrocytoma and lung adenocarcinoma. Recent reports also indicate that CD63 is a good prognostic biomarker for human astrocytomas and earlier stages of lung carcinoma. Additionally, CD63 has been useful in differentiating renal oncocytomas (RO) from eosinophilic variants of chromophobe renal cell carcinomas Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse
7 ml more info 14 days
€187,20 Add to cart -
CD64/IGFR1 Polyclonal
Description This antibody recognizes CD64 also known as FcRI. CD64 is a high affinity activatory receptor for IgG2a and a low affinity receptor for IgG2b and IgG3 type antibodies. The interaction between Fc receptors and antibodies play important roles in both the innate and adaptive immune responses. CD64 through binding of the Fc segment of IgG, mediates phagocytosis and plays a role in antibody-dependent cellular cytotoxicity and clearance of immune complexes. In addition, CD64 also functions as an antigen capture for presentation to T-cells and also mediates the release of cytokines and reactive oxygen intermediates including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) alpha. It is constitutively expressed on monocytes and macrophages, germinal centre dendritic cells and early myeloid lineage cells, but not lymphocytes. Expression on monocytes can be strongly upregulated by treatment with interferon (IFN) gamma or G-CSF, and can be induced on neutrophils and eosinophils by IFN gam Host Rabbit Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€455,00 Add to cart -
CD64/IGFR1 Polyclonal
Description This antibody recognizes CD64 also known as FcRI. CD64 is a high affinity activatory receptor for IgG2a and a low affinity receptor for IgG2b and IgG3 type antibodies. The interaction between Fc receptors and antibodies play important roles in both the innate and adaptive immune responses. CD64 through binding of the Fc segment of IgG, mediates phagocytosis and plays a role in antibody-dependent cellular cytotoxicity and clearance of immune complexes. In addition, CD64 also functions as an antigen capture for presentation to T-cells and also mediates the release of cytokines and reactive oxygen intermediates including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) alpha. It is constitutively expressed on monocytes and macrophages, germinal centre dendritic cells and early myeloid lineage cells, but not lymphocytes. Expression on monocytes can be strongly upregulated by treatment with interferon (IFN) gamma or G-CSF, and can be induced on neutrophils and eosinophils by IFN gam Host Rabbit Application ELISA, Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€254,80 Add to cart
