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Osteonectin/SPARC/BM40 [MD18R]
Description Bone matrix consists of collagen and non-collagenous proteins. Osteonectin, a 32-kD calcium-binding glycoprotein, is found in a variety of cell types, which include osteoblastic epithelial cells and fibroblasts. In bone tissue, this glycoprotein is present in active osteoblasts and young osteocytes, and it is involved in the early steps of mineralization of skeletal tissue. Osteonectin is a recognized differentiation marker of normal osteogenic cells.The latter represents about 10% of the total protein content of bone. Osteonectin is one of the non-collagenous components and is bone-specific due to its biochemical properties. Osteonectin is a useful biochemical marker for bone-related tumors. Thus, osteonectin antibody can be used to demonstrate the presence of osteonectin in active osteoblasts and osteoprogenitor cells as well as in young osteocytes. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
7 ml more info 
14 days 
€254,80 Add to cart -
Osteopontin (EPR21139-316]
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€494,00 Add to cart -
Osteopontin (EPR21139-316]
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat 
1 ml more info 14 days
€374,40 Add to cart -
Osteopontin Polyclonal
Description Osteopontin, also known as Phosphoprotein 1 (SPP1), is an acidic, calcium-binding glycol-phosphoprotein of 44 to 66 kDa, depending on species and cell type. Osteopontin interacts with integrins and CD44. It has been shown to be multifunctional in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, development and regeneration of skeletal muscle, and control of tumor cell phenotype. Osteopontin is found in all body fluids and secreted by osteoclasts, macrophages, cardiac fibroblasts, and activated T cells. Immunohistochemical analysis shows that Osteopontin is widely expressed in many types of cells including epithelial cells of the gastrointestinal tract, gall bladder, pancreas, urinary and reproductive tracts, lung, breast, salivary glands, and sweat glands. Osteopontin is overexpressed in a variety of human malignancies, including breast, lung, ovarian, gastric, hepatocellular, and prostate carcinomas, mesothelioma, and melanoma. It was pro Host Rabbit Application ELISA, Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human, Mouse, Rat
7 ml more info 14 days
€174,20 Add to cart -
p120 Catenin [MD153R]
Description Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is a member of this Armadillo gene family of junctional plaque proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Cytoplasmic accumulation of p120 Catenin has been observed in lung cancer, pancreatic cancer, gastric cancer and colon cancers and is associated with poor progress in colon cancer patients. In breast lobular neoplasia, p120 Catenin shows a diffuse cytoplasmic immunostaining pattern, while breast ductal neoplasia retains the membrane immunostaining pattern. p120 Catenin is useful in differentiation of lobular carcinoma from ductal carcinoma of the breast and in identifying early lesions of lobular neoplasia (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart -
p120 Catenin [MD153R]
Description Catenins are proteins that are linked to the cytoplasmic domain of transmembrane cadherins. p120 Catenin is a member of this Armadillo gene family of junctional plaque proteins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be important for cadherins cell-adhesion properties. Cytoplasmic accumulation of p120 Catenin has been observed in lung cancer, pancreatic cancer, gastric cancer and colon cancers and is associated with poor progress in colon cancer patients. In breast lobular neoplasia, p120 Catenin shows a diffuse cytoplasmic immunostaining pattern, while breast ductal neoplasia retains the membrane immunostaining pattern. p120 Catenin is useful in differentiation of lobular carcinoma from ductal carcinoma of the breast and in identifying early lesions of lobular neoplasia (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€214,50 Add to cart -
p16/INK4a [CDKN2A/4844R]
Description p16/INK4A is a tumor-suppressor protein and that genetic and epigenetic abnormalities in genes controlling the G1 checkpoint can lead to both escape from senescence and cancer formation. The interaction of p16/INK4 family members can be a binary complex with CDK4/6 or ternary complex with cyclin D-bound CDK4/6 and ultimately results in the inhibition of cell cycle progression. As such, expression of p16 INK4A is commonly associated with cellular senescence, and disruption of the p16 INK4A gene is frequently observed in human tumor. The p16/INK4A locus is deleted in a wide spectrum of tumors including melanoma, pancreatic adenocarcinoma, glioblastoma, certain leukemias, non-small cell lung cancer, cervical cancer, and bladder carcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€390,00 Add to cart -
p16/INK4a [CDKN2A/4844R]
Description p16/INK4A is a tumor-suppressor protein and that genetic and epigenetic abnormalities in genes controlling the G1 checkpoint can lead to both escape from senescence and cancer formation. The interaction of p16/INK4 family members can be a binary complex with CDK4/6 or ternary complex with cyclin D-bound CDK4/6 and ultimately results in the inhibition of cell cycle progression. As such, expression of p16 INK4A is commonly associated with cellular senescence, and disruption of the p16 INK4A gene is frequently observed in human tumor. The p16/INK4A locus is deleted in a wide spectrum of tumors including melanoma, pancreatic adenocarcinoma, glioblastoma, certain leukemias, non-small cell lung cancer, cervical cancer, and bladder carcinoma. (Shipping Cost: €200.00) Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€214,50 Add to cart -
p40 [MD6R]
Description p63 consists of two major isoforms-TAp63 and ΔNp63. These isoforms differ in the structure of the Nterminal domains. The TAp63 isoform identified by anti-p63 antibody) contains a transactivation-competent ‘TA’ domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, ΔNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive ‘ΔN’ domain, which antagonizes the activity of TAp63 and p53. The p40 (clone ZR8) antibody recognizes exclusively ΔNp63 but not TAp63. p40 is a squamous cell carcinoma ‘specific’ antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated denocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€416,00 Add to cart
