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FOXP1 [MD189R]
Description The FOXP1 protein belongs to a functionally diverse family of winged-helix or forkhead transcription factors that have diverse roles in cellular proliferation, differentiation, and neoplastic transformation. The FOXP1 gene has been mapped to chromosome 3p14.1, a region that commonly shows loss of heterozygosity in a wide range of tumors and is reported to contain a tumor suppressor gene(s). The FOXP1 protein is widely expressed in normal human tissues. It labels activated B cells in the mantle zone and germinal center of lymphoid tissues. In lymphoid malignancies, FOXP1 protein expression may be found in diffuse large B-cell lymphomas and extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). Strong expression of FOXP1 is associated with poor disease-free survival and transformation to diffuse large Bcell lymphomas. Recently, studies suggested a role of FOXP1 in the regulation of ER expression. FOXP1 expression is correlated with ER expression and improv Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human 
1 ml more info 
14 days 
€442,00 Add to cart -
FOXP1 [MD189R]
Description The FOXP1 protein belongs to a functionally diverse family of winged-helix or forkhead transcription factors that have diverse roles in cellular proliferation, differentiation, and neoplastic transformation. The FOXP1 gene has been mapped to chromosome 3p14.1, a region that commonly shows loss of heterozygosity in a wide range of tumors and is reported to contain a tumor suppressor gene(s). The FOXP1 protein is widely expressed in normal human tissues. It labels activated B cells in the mantle zone and germinal center of lymphoid tissues. In lymphoid malignancies, FOXP1 protein expression may be found in diffuse large B-cell lymphomas and extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). Strong expression of FOXP1 is associated with poor disease-free survival and transformation to diffuse large Bcell lymphomas. Recently, studies suggested a role of FOXP1 in the regulation of ER expression. FOXP1 expression is correlated with ER expression and improv Host Rabbit Application Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€234,00 Add to cart
