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NDRG1 [MD34R]
Description The N-myc downregulated gene 1 (NDRG1) is a 43 KDa protein that contains a NDRG1 core domain and three unique tandem repeats of 10 hydrophilic amino acids near the COOH terminus, which is ubiquitously expressed in different mammalian tissues and modulates cell growth, differentiation and apoptosis. Although the exact biological function of NDRG1 remains obscure, studies suggest that NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 has been identified as a protein involved in the differentiation of epithelial cells. One of the most well documented links between NDRG1and pathophysiology is its association with inhibition of tumor metastasis. The reduced expression of NDRG1 was found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. On the other hand, overexpression of NDRG1 in hepatocellular carcinoma has been an indicator of tumor aggressiveness. Cel Host Rabbit Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey 
1 ml more info 
14 days 
€494,00 Add to cart -
NDRG1 [MD34R]
Description The N-myc downregulated gene 1 (NDRG1) is a 43 KDa protein that contains a NDRG1 core domain and three unique tandem repeats of 10 hydrophilic amino acids near the COOH terminus, which is ubiquitously expressed in different mammalian tissues and modulates cell growth, differentiation and apoptosis. Although the exact biological function of NDRG1 remains obscure, studies suggest that NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 has been identified as a protein involved in the differentiation of epithelial cells. One of the most well documented links between NDRG1and pathophysiology is its association with inhibition of tumor metastasis. The reduced expression of NDRG1 was found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. On the other hand, overexpression of NDRG1 in hepatocellular carcinoma has been an indicator of tumor aggressiveness. Cel Host Rabbit Application Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human, Monkey
7 ml more info 14 days
€254,80 Add to cart
