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SUMO-2/3 [SM23/496]
Description The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing including nuclear transport, transcriptional regulation, apoptosis, and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human 
7 ml more info 
14 days 
€187,20 Add to cart -
Surfactant/SP-D [MD165R]
Description Pulmonary surfactant is primarily responsible for lowering the surface tension at the air-liquid interface in the alveoli, a process that is essential for normal respiration. Pulmonary surfactant is a mixture of phospholipids and proteins, including four distinct surfactant-associated proteins (SPs): SP-A, SP-B, SP-C, and SP-D. SP-B and SP-C showed strong immunohistochemical expression in Lung Hyperplasias and Adenomas, suggesting that SP-B and SP-C are related to lung tumorigenesis. SP-A and SP-D are large multimeric proteins belonging to the family of calcium-dependent lectins, designated Collectins, which contribute to the innate immune system. SP-D is a protein encoded by the SFTPD gene. Studies found low expression of SF-D expression in lung, gastric, and breast cancers and high expression in different stages and grades of ovarian cancer. SF-D expression could be associated with a favorable prognosis in lung cancer but unfavorable in non-pulmonary sites such as breast, gastric and Host Rabbit Application Flow cytometry (FC), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€374,40 Add to cart -
TAG-72/CA72.4 [B72.3]
Description Tumor-Associated Glycoprotein 72 (TAG-72) is an oncofetal mucin antigen expressed by normal secretory endometrium and most human adenocarcinomas, including colorectal, gastric, pancreatic, mammary, and ovarian. Antibody B72.3 recognizes a carbohydrate epitope identified as sialylated Tn antigen. This antigen is expressed by invasive ductal breast carcinomas, colon, pancreatic, gastric, esophageal, lung, ovarian and endometrial adenocarcinomas. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas, or benign tumors. This antigen is also expressed on normal secretory endometrium, but not on other normal tissues. TAG-72 expression in fetal tissue is only observed in tissues of the gastrointestinal tract, including the colon, esophagus and stomach. No reactivity is seen with tissue from other organ systems, including the lymphoreticular, cardiovascular, hepatic, pulmonary, neural, muscular, skin, endocrine and genitourinary tissues. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine, Dog (Canine), Hamster, Rat
1 ml more info 14 days
€361,40 Add to cart -
TAG-72/CA72.4 [B72.3]
Description Tumor-Associated Glycoprotein 72 (TAG-72) is an oncofetal mucin antigen expressed by normal secretory endometrium and most human adenocarcinomas, including colorectal, gastric, pancreatic, mammary, and ovarian. Antibody B72.3 recognizes a carbohydrate epitope identified as sialylated Tn antigen. This antigen is expressed by invasive ductal breast carcinomas, colon, pancreatic, gastric, esophageal, lung, ovarian and endometrial adenocarcinomas. It is not expressed by leukemias, lymphomas, sarcomas, mesotheliomas, melanomas, or benign tumors. This antigen is also expressed on normal secretory endometrium, but not on other normal tissues. TAG-72 expression in fetal tissue is only observed in tissues of the gastrointestinal tract, including the colon, esophagus and stomach. No reactivity is seen with tissue from other organ systems, including the lymphoreticular, cardiovascular, hepatic, pulmonary, neural, muscular, skin, endocrine and genitourinary tissues. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Bovine, Dog (Canine), Hamster, Rat
7 ml more info 14 days
€187,20 Add to cart -
Tartarate Resistant Acid Phosphatase (TRAcP/TRAP5) [ACP5/1070]
Description Tartrate resistant acid phosphatase (TRAcP) is a basic, iron-binding protein with high activity towards phosphoproteins, ATP and 4 nitrophenyl phosphate. Expression of TRAcP is reported to be increased in the spleen and monocytes of individuals with Gaucher’s disease, splenocytes and circulating white cells of individuals with hairy cell leukemia, spleens of individuals with Hodgkin disease, and the sera of individuals undergoing active bone turnover. Elevated levels are also reported to be associated with various B-cell and T-cell leukemias and lymphomas, placental decidual cells, syncytiotrophoblasts, and some macrophages distributed throughout maternal and embryonic tissues. The histochemical identification of hairy cell leukemia via tartrate-resistant acid phosphatase assay has been a standard for over two decades. Anti-TRAcP labels the cells of hairy cell leukemia (HCL) with a high degree of sensitivity and specificity. Worthy also of mention in this regard are anti-annexin A1 and Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse,Rat
1 ml more info 14 days
€361,40 Add to cart -
Tartarate Resistant Acid Phosphatase (TRAcP/TRAP5) [ACP5/1070]
Description Tartrate resistant acid phosphatase (TRAcP) is a basic, iron-binding protein with high activity towards phosphoproteins, ATP and 4 nitrophenyl phosphate. Expression of TRAcP is reported to be increased in the spleen and monocytes of individuals with Gaucher’s disease, splenocytes and circulating white cells of individuals with hairy cell leukemia, spleens of individuals with Hodgkin disease, and the sera of individuals undergoing active bone turnover. Elevated levels are also reported to be associated with various B-cell and T-cell leukemias and lymphomas, placental decidual cells, syncytiotrophoblasts, and some macrophages distributed throughout maternal and embryonic tissues. The histochemical identification of hairy cell leukemia via tartrate-resistant acid phosphatase assay has been a standard for over two decades. Anti-TRAcP labels the cells of hairy cell leukemia (HCL) with a high degree of sensitivity and specificity. Worthy also of mention in this regard are anti-annexin A1 and Host Mouse Application Flow cytometry (FC), Immunocytochemistry (ICC),Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human, Mouse,Rat
7 ml more info 14 days
€187,20 Add to cart -
T-bet/TBX21 [MD40R]
Description T-box transcription factor TBX21, also known as T-bet, is a member of the T-box family of transcription factors. It has been confirmed that TBX21 is the key lineage-defining transcription factor that directs the development Th1 cells and is directly responsible for the transactivation of the interferon-γ (IFN-γ) gene. TBX21 is expressed in CD4+ T lymphocytes in normal tissues. In lymphoid malignancies, TBX21 has been found in a subset of T-cell lymphomas with Th1 T-cell differentiation, a subset of B-cell or T cells, non-Hodgkin's lymphomas, majority of Hodgkin's lymphomas and precursor B-cell lymphoblastic leukemia/lymphoblastic lymphomas. However, TBX21 is not expressed in diffuse large B-cell lymphoma and most cases of anaplastic large cell lymphoma. TBX21 is a useful new marker for Hodgkin's lymphoma. TBX21 is also helpful in identification of hairy cell leukemia (HCL). Ventana/Cell Marque have. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
1 ml more info 14 days
€401,70 Add to cart -
T-bet/TBX21 [MD40R]
Description T-box transcription factor TBX21, also known as T-bet, is a member of the T-box family of transcription factors. It has been confirmed that TBX21 is the key lineage-defining transcription factor that directs the development Th1 cells and is directly responsible for the transactivation of the interferon-γ (IFN-γ) gene. TBX21 is expressed in CD4+ T lymphocytes in normal tissues. In lymphoid malignancies, TBX21 has been found in a subset of T-cell lymphomas with Th1 T-cell differentiation, a subset of B-cell or T cells, non-Hodgkin's lymphomas, majority of Hodgkin's lymphomas and precursor B-cell lymphoblastic leukemia/lymphoblastic lymphomas. However, TBX21 is not expressed in diffuse large B-cell lymphoma and most cases of anaplastic large cell lymphoma. TBX21 is a useful new marker for Hodgkin's lymphoma. TBX21 is also helpful in identification of hairy cell leukemia (HCL). Ventana/Cell Marque have. (Shipping Cost: €200.00) Host Rabbit Application Flow cytometry (FC), Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB) Reactivity Human
7 ml more info 14 days
€254,80 Add to cart -
Tenascin [T2H5]
Description Tenascin is a high molecular weight, multifunctional, hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
1 ml more info 14 days
€361,40 Add to cart -
Tenascin [T2H5]
Description Tenascin is a high molecular weight, multifunctional, hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neovasculature and stroma of undifferentiated tumors. (Shipping Cost: €200.00) Host Mouse Application Flow cytometry (FC), Immunofluorescence (IF), Immunohistochemistry (IHC) Reactivity Human
7 ml more info 14 days
€187,20 Add to cart
