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p53 [BP-53-12]
| Product group: | Primary |
| Monoclonal/ Polyclonal: | Monoclonal |
| Clone: | BP-53-12 |
| Host: | Mouse |
| Isotype: | IgG2a |
| Application: | Immunohistochemistry (IHC) |
| Application notes: | 50-200 |
| Conjugation Type: | Unconjugated |
| Reactivity: | Human |
| General notes: | Localization: nucleus. |
| Buffer: | citrate pH6.0 or EDTA pH8.0 |
| UNSPSC code: | 12352203 |
p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 is overexpressed in over 50% of human cancers. Positive staining of p53 detected by immunohistochemistry has been observed in colon cancer, breast cancer, lung cancer, prostate cancer and ovary cancer. (Shipping Cost: €200.00)
p53 [BP-53-12]
p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair. p53 is overexpressed in over 50% of human cancers. Positive staining of p53 detected by immunohistochemistry has been observed in colon cancer, breast cancer, lung cancer, prostate cancer and ovary cancer.
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