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Neurofilament [NF421]
Product group: | Primary |
Monoclonal/ Polyclonal: | Monoclonal |
Clone: | NF421 |
Host: | Mouse |
Isotype: | IgG1 |
Application: | Flow cytometry (FC), Immunohistochemistry (IHC) |
Application notes: | 100-300 |
Conjugation Type: | Unconjugated |
Reactivity: | Human, Mouse, Rat,Pig (Porcine), Chicken |
General notes: | Localization: cytoplasm. |
UNSPSC code: | 12352203 |
Neuofilaments (NF) are members of the intermediate filament protein family. These neuron-specific filaments are the major constituents of the axonal cytoskeleton . NFs are composed of three major proteins: NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa). The NF-L and NF-M mRNAs are detected early in the embryonal brain, with a progressive increase in their levels during development, while the NF-H mRNA is barely detectable at embryonal stages but accumulates later in the postnatal brain. This antibody labels neurons of the central and peripheral nervous system, and is a useful for the identification of tumors with neuronal differentiation (Shipping Cost: €200.00)
Neurofilament [NF421]
Neuofilaments (NF) are members of the intermediate filament protein family. These neuron-specific filaments are the major constituents of the axonal cytoskeleton . NFs are composed of three major proteins: NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa). The NF-L and NF-M mRNAs are detected early in the embryonal brain, with a progressive increase in their levels during development, while the NF-H mRNA is barely detectable at embryonal stages but accumulates later in the postnatal brain. This antibody labels neurons of the central and peripheral nervous system, and is a useful for the identification of tumors with neuronal differentiation
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